5,7-Dichloro-8-hydroxyquinoline

Toxicity

The toxicological properties of this material have not been investigated.

Description

Chloroxine, a dichloroquinolinol, was first prepared by A. Hebebrand in 1888. It is an antibacterial drug that has been incorporated into shampoos to treat dandruff and seborrheic dermatitis. It has also been used internally as an antidiarrheal and in the lab as an analytical reagent.

Chemical properties

light beige fluffy powder

The Uses of 5,7-Dichloro-8-hydroxyquinoline

H1 antihistamine

The Uses of 5,7-Dichloro-8-hydroxyquinoline

Analytical reagent.

The Uses of 5,7-Dichloro-8-hydroxyquinoline

Chloroxine, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.

Background

Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.

Indications

Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.

What are the applications of Application

5,7-Dichloro-8-quinolinol is a synthetic antibacterial compound

Definition

ChEBI: Quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. An synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp.

Indications

Chloroxine (Capitrol) shampoo contains a synthetic antibacterial compound similar to the hydroxyquinoline compounds used in dermatology for many years.

brand name

Capitrol (Westwood- Squibb).

Pharmacokinetics

Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms. Also, chloroxine has shown some antifungal activity against certain dermatophytes and yeasts.

Metabolism

Not Available

Purification Methods

Crystallise the dichloro-oxine from acetone/EtOH. [Beilstein 21 H 95.]