5,7-Dichloro-8-hydroxyquinoline
Synonym(s):5,7-Dichloro-8-hydroxyquinoline;Chloroxine
- CAS NO.:773-76-2
- Empirical Formula: C9H5Cl2NO
- Molecular Weight: 214.05
- MDL number: MFCD00006786
- EINECS: 212-258-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:03
What is 5,7-Dichloro-8-hydroxyquinoline?
Toxicity
The toxicological properties of this material have not been investigated.
Description
Chloroxine, a dichloroquinolinol, was first prepared by A. Hebebrand in 1888. It is an antibacterial drug that has been incorporated into shampoos to treat dandruff and seborrheic dermatitis. It has also been used internally as an antidiarrheal and in the lab as an analytical reagent.
Chemical properties
light beige fluffy powder
The Uses of 5,7-Dichloro-8-hydroxyquinoline
H1 antihistamine
The Uses of 5,7-Dichloro-8-hydroxyquinoline
Analytical reagent.
The Uses of 5,7-Dichloro-8-hydroxyquinoline
Chloroxine, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.
Indications
Chloroxine (Capitrol) shampoo contains a synthetic antibacterial compound similar to the hydroxyquinoline compounds used in dermatology for many years.
Background
Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.
Definition
ChEBI: Quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. An synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp.
Indications
Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.
What are the applications of Application
5,7-Dichloro-8-quinolinol is a synthetic antibacterial compound
brand name
Capitrol (Westwood- Squibb).
Pharmacokinetics
Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms. Also, chloroxine has shown some antifungal activity against certain dermatophytes and yeasts.
Metabolism
Not Available
Purification Methods
Crystallise the dichloro-oxine from acetone/EtOH. [Beilstein 21 H 95.]
Properties of 5,7-Dichloro-8-hydroxyquinoline
Melting point: | 178-180 °C (lit.) |
Boiling point: | 305.47°C (rough estimate) |
Density | 1.3320 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, H |
form | Fluffy Powder |
pka | 2.30±0.30(Predicted) |
color | Light beige |
Merck | 14,2175 |
BRN | 153606 |
Stability: | Light Sensitive |
CAS DataBase Reference | 773-76-2(CAS DataBase Reference) |
NIST Chemistry Reference | 8-Quinolinol, 5,7-dichloro-(773-76-2) |
EPA Substance Registry System | 8-Quinolinol, 5,7-dichloro- (773-76-2) |
Safety information for 5,7-Dichloro-8-hydroxyquinoline
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 5,7-Dichloro-8-hydroxyquinoline
Abamectin manufacturer
Auro Pharmaceuticals And Fine Chemicals Pvt Ltd
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