5-Chloro-8-hydroxyquinoline
Synonym(s):5-Chloro-8-hydroxyquinoline
- CAS NO.：130-16-5
- Empirical Formula: C9H6ClNO
- Molecular Weight: 179.6
- MDL number: MFCD00006788
- EINECS: 204-978-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-14 18:30:21
What is 5-Chloro-8-hydroxyquinoline?
Chemical properties
light green to grey powder
The Uses of 5-Chloro-8-hydroxyquinoline
antibacterial, antifungal
The Uses of 5-Chloro-8-hydroxyquinoline
Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.
Definition
ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.
Synthesis Reference(s)
The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x
in vitro
Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.
in vivo
Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.
Properties of 5-Chloro-8-hydroxyquinoline
| Melting point: | 122-124 °C(lit.) |
| Boiling point: | 348.7±22.0 °C(Predicted) |
| Density | 1.2364 (rough estimate) |
| vapor pressure | 0.003Pa at 25℃ |
| refractive index | 1.5330 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 0.019g/l (experimental) |
| pka | 3.77±0.10(Predicted) |
| form | Powder |
| color | Light green to gray |
| Sensitive | Light Sensitive |
| Merck | 14,2422 |
| BRN | 5289 |
| CAS DataBase Reference | 130-16-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 8-Quinolinol, 5-chloro-(130-16-5) |
| EPA Substance Registry System | 8-Quinolinol, 5-chloro- (130-16-5) |
Safety information for 5-Chloro-8-hydroxyquinoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Chloro-8-hydroxyquinoline
| InChIKey | RWPWQYXFGFYJBA-UHFFFAOYSA-N |
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