5-Chloro-8-hydroxyquinoline
Synonym(s):5-Chloro-8-hydroxyquinoline
- CAS NO.：130-16-5
- Empirical Formula: C9H6ClNO
- Molecular Weight: 179.6
- MDL number: MFCD00006788
- EINECS: 204-978-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is 5-Chloro-8-hydroxyquinoline?
Chemical properties
light green to grey powder
The Uses of 5-Chloro-8-hydroxyquinoline
antibacterial, antifungal
The Uses of 5-Chloro-8-hydroxyquinoline
Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.
Definition
ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.
Synthesis Reference(s)
The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x
in vitro
Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.
in vivo
Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.
Properties of 5-Chloro-8-hydroxyquinoline
| Melting point: | 122-124 °C(lit.) |
| Boiling point: | 348.7±22.0 °C(Predicted) |
| Density | 1.2364 (rough estimate) |
| vapor pressure | 0.003Pa at 25℃ |
| refractive index | 1.5330 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 0.019g/l (experimental) |
| pka | 3.77±0.10(Predicted) |
| form | Powder |
| color | Light green to gray |
| Sensitive | Light Sensitive |
| Merck | 14,2422 |
| BRN | 5289 |
| CAS DataBase Reference | 130-16-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 8-Quinolinol, 5-chloro-(130-16-5) |
| EPA Substance Registry System | 8-Quinolinol, 5-chloro- (130-16-5) |
Safety information for 5-Chloro-8-hydroxyquinoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Chloro-8-hydroxyquinoline
| InChIKey | RWPWQYXFGFYJBA-UHFFFAOYSA-N |
5-Chloro-8-hydroxyquinoline manufacturer
Auro Pharmaceuticals And Fine Chemicals Pvt Ltd
1Y
Phone:+91-8087324189
Whatsapp: +91- 8087324189
product: Cloxyquin 98%
Prerana Chemical Industries
1Y
Phone:+91-9824150584
Whatsapp: +91-9824150584
product: Cloxyquin 130-16-5 99%
Suryaprabha Pharmachem
1Y
Phone:+91-9850308282
Whatsapp: +91-9850308282
product: 130-16-5 Cloxyquin 99%
SPARKVEE FINE CHEMICALS PRIVATE LIMITED
1Y
Phone:+91-9177992371
Whatsapp: +91-9177992371
product: 5-chloro-8-hydroxyquinoline NLT 98%
New Products
p-Toluenesulfonyl hydrazide N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one ELECTROLYTIC IRON POWDER 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 4-HYDROXY BENZYL ALCOHOL 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) 1-(2,4-DICHLOROPHENYL) ETHANAMINE 4-Bromopyrazole 1-Boc-4-cyanopiperidine 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone Cycloleucine 1-Aminocyclobutanecarboxylic acid 1-Amino-1-cyclohexanecarboxylic acid 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride TETRABUTYLAMMONIUM CYANIDE Ethyl 2-cyano-2-(hydroxyimino)acetate (S)-1-Benzyl 2-methyl pyrrolidine-1,2-dicarboxylate 2-Amino-3-nitrobenzoic acid methyl ester N1,N2-Dibenzylethane-1,2-diamine 3-(4-Morpholinyl)aniline 4-methoxy-3,5-dinitropyridineRelated products of tetrahydrofuran
![6-CHLORO-3-(3,4-DICHLOROBENZYL)-3,4-DIHYDRO-2H-[1,3]OXAZINO[5,6-H]QUINOLINE](https://img.chemicalbook.in/StructureFile/ChemBookStructure4/GIF/CB1285145.gif)
You may like
-
5- Chloro - 8 - Hydroxyquinoline 98%View Details -
Cloxyquin 99%View Details -
5-Chloro-8-hydroxyquinoline, 95% CAS 130-16-5View Details
130-16-5 -
130-16-5 Cloxyquin 98%View Details
130-16-5 -
Cloxyquin 130-16-5 98%View Details
130-16-5 -
Cloxyquin 98%View Details -
5-Chloro-8-hydroxyquinoline CAS 130-16-5View Details
130-16-5 -
5-Chloro-8-quinolinol CAS 130-16-5View Details
130-16-5
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.