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HomeProduct name list5-Bromopyrimidine

5-Bromopyrimidine

  • CAS NO.:4595-59-9
  • Empirical Formula: C4H3BrN2
  • Molecular Weight: 158.98
  • MDL number: MFCD00006117
  • EINECS: 224-992-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
5-Bromopyrimidine Structural

What is 5-Bromopyrimidine?

Chemical properties

yellow solid crystalline, insoluble in water, soluble in organic solvents such as benzene and toluene.

The Uses of 5-Bromopyrimidine

5-Bromopyrimidine was used in the synthesis of N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction, (5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol.

The Uses of 5-Bromopyrimidine

5-Bromopyrimidine was used in the synthesis of:
N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction
(5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol
Intermediate for the synthesis of plant growth regulator flurprimidol

What are the applications of Application

5-Bromopyrimidine is a compound useful in organic synthesis.

Preparation

5-Bromopyrimidine is prepared by reacting dibromodifuranone with formamide in the presence of B2O2 catalyst at 180-185°C to obtain the product.

General Description

Rapid nucleophilic displacement reactions of 5-bromopyrimidine with nucleophiles under microwave irradiation has been studied. 5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine.

Properties of 5-Bromopyrimidine

Melting point: 67-73 °C (lit.)
Boiling point: 168°C(lit.)
Density  1.6448 (rough estimate)
refractive index  1.5260 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Soluble in chloroform.
pka 1.40±0.10(Predicted)
form  Crystalline Powder or Chunks
color  Yellow to beige-brown
BRN  107326
CAS DataBase Reference 4595-59-9(CAS DataBase Reference)
NIST Chemistry Reference Pyrimidine, 5-bromo-(4595-59-9)
EPA Substance Registry System Pyrimidine, 5-bromo- (4595-59-9)

Safety information for 5-Bromopyrimidine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-Bromopyrimidine

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