2-Amino-5-bromopyrimidine

Chemical properties

Yellow Solid

The Uses of 2-Amino-5-bromopyrimidine

2-Amino-5-bromopyrimidine was employed:

• in synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites
• in synthesis of 2-phthalimido-5-bromopyrimidine
• as intermediate for the preparation of sulfanilamides and amino acids containing the pyrimidine ring system. The products are potential antiviral agents

What are the applications of Application

5-Bromo-2-aminopyrimidine is used in synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites

General Description

Crystal structure of 2-amino-5-bromopyrimidine was studied.

Synthesis

The synthesis of 2-Amino-5-bromopyrimidine is as follows:The 2-aminopyrimidine (2.5g, 26.29mmol) was dissolved in acetonitrile (25mL) was added N- bromosuccinimide (4.6g, 27.9mmol) under ice-cooling, stirred in the dark overnight at room temperature. Recovery of the solvent under reduced pressure, washed with water (100 mL) was washed, filtered off with suction, and dried in vacuo to give a white solid. Yield: 97%.

storage

Store in cool, well ventilated area. Keep container tightly closed. Light sensitive. Store under argon.