4,5-Dimethylthiazole
- CAS NO.:3581-91-7
- Empirical Formula: C5H7NS
- Molecular Weight: 113.18
- MDL number: MFCD00005336
- EINECS: 222-703-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-24 13:33:21
What is 4,5-Dimethylthiazole?
Chemical properties
4,5-Dimethylthiazole is a colorless to light yellow liquid that has a roasted nutty, meaty, boiled poultry-like odor.
Occurrence
Reported found in peanuts, toasted oats, malt, peach, pork, coffee, krill, shrimp and scallops
The Uses of 4,5-Dimethylthiazole
4,5-Dimethylthiazole was used in the preparation of 4-(bromomethyl)-5-(dibromomethyl)thiazole.
Preparation
From methyl-α-bromoethyl ketone; by oxidation of 2-mercaptothiazoles with hydrogen peroxide in aqueous solution; from 2-mercapto-4,5-dimethylthiazole.
Definition
ChEBI: 4,5-Dimethylthiazole is a member of thiazoles.
Aroma threshold values
Detection: 470 ppb
Taste threshold values
Taste characteristics at 5 ppm: fishy, amine and pyridine-like with shrimp and savory nuances
Synthesis Reference(s)
The Journal of Organic Chemistry, 6, p. 764, 1941 DOI: 10.1021/jo01205a011
General Description
4,5-Dimethylthiazole is a thiazoles compounds that containing a thiazole ring substituted at positions 4 and 5 only. Radical bromination of 4,5-dimethylthiazole using N-bromosuccinimide in the presence of 2,2′-azobisisobutyronitrile yields mono-, tri- and tetrabromo compounds.
Properties of 4,5-Dimethylthiazole
Melting point: | 83-84 C |
Boiling point: | 158 °C/742 mmHg (lit.) |
Density | 1.07 g/mL at 25 °C (lit.) |
refractive index | n |
FEMA | 3274 | 4,5-DIMETHYLTHIAZOLE |
Flash point: | 124 °F |
storage temp. | Sealed in dry,Room Temperature |
form | solid |
pka | pK1:3.73 (25°C,μ=0.1) |
Specific Gravity | 1.070 |
Odor | at 0.10 % in dipropylene glycol. roasted nutty fishy green boiled shrimp |
JECFA Number | 1035 |
BRN | 105694 |
CAS DataBase Reference | 3581-91-7(CAS DataBase Reference) |
NIST Chemistry Reference | Thiazole, 4,5-dimethyl-(3581-91-7) |
Safety information for 4,5-Dimethylthiazole
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4,5-Dimethylthiazole
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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