4,5-Dimethylthiazole
- CAS NO.:3581-91-7
- Empirical Formula: C5H7NS
- Molecular Weight: 113.18
- MDL number: MFCD00005336
- EINECS: 222-703-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-24 13:33:21
What is 4,5-Dimethylthiazole?
Chemical properties
4,5-Dimethylthiazole is a colorless to light yellow liquid that has a roasted nutty, meaty, boiled poultry-like odor.
Occurrence
Reported found in peanuts, toasted oats, malt, peach, pork, coffee, krill, shrimp and scallops
The Uses of 4,5-Dimethylthiazole
4,5-Dimethylthiazole was used in the preparation of 4-(bromomethyl)-5-(dibromomethyl)thiazole.
Preparation
From methyl-α-bromoethyl ketone; by oxidation of 2-mercaptothiazoles with hydrogen peroxide in aqueous solution; from 2-mercapto-4,5-dimethylthiazole.
Definition
ChEBI: 4,5-Dimethylthiazole is a member of thiazoles.
Aroma threshold values
Detection: 470 ppb
Taste threshold values
Taste characteristics at 5 ppm: fishy, amine and pyridine-like with shrimp and savory nuances
Synthesis Reference(s)
The Journal of Organic Chemistry, 6, p. 764, 1941 DOI: 10.1021/jo01205a011
General Description
4,5-Dimethylthiazole is a thiazoles compounds that containing a thiazole ring substituted at positions 4 and 5 only. Radical bromination of 4,5-dimethylthiazole using N-bromosuccinimide in the presence of 2,2′-azobisisobutyronitrile yields mono-, tri- and tetrabromo compounds.
Properties of 4,5-Dimethylthiazole
Melting point: | 83-84 C |
Boiling point: | 158 °C/742 mmHg (lit.) |
Density | 1.07 g/mL at 25 °C (lit.) |
refractive index | n |
FEMA | 3274 | 4,5-DIMETHYLTHIAZOLE |
Flash point: | 124 °F |
storage temp. | Sealed in dry,Room Temperature |
form | solid |
pka | pK1:3.73 (25°C,μ=0.1) |
Specific Gravity | 1.070 |
Odor | at 0.10 % in dipropylene glycol. roasted nutty fishy green boiled shrimp |
JECFA Number | 1035 |
BRN | 105694 |
CAS DataBase Reference | 3581-91-7(CAS DataBase Reference) |
NIST Chemistry Reference | Thiazole, 4,5-dimethyl-(3581-91-7) |
Safety information for 4,5-Dimethylthiazole
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4,5-Dimethylthiazole
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen 4-Hydroxy Carbazole 4-((2-isopropoxyethoxy)methyl)phenol 2 – Methoxy – 5- Sulfamoyl Benzoic acid Amino Salicylic Acid. U.S.P. 1,2,3,4-Tetrahydrocarbazol-4-one Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract (S)-4-(4-(5-(Aminomethyl)-2-Oxooxazolidin-3-Yl)Phenyl)Mo Ethyl N-[[2-[[[4-(Aminoiminomethyl)Phenyl]Amino]Methyl] 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/ Cypermethric Acid Chloride Methyl Di Chloride (Mdc)Related products of tetrahydrofuran
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