4-Hydroxythiobenzamide
- CAS NO.：25984-63-8
- Empirical Formula: C7H7NOS
- Molecular Weight: 153.2
- MDL number: MFCD04973332
- EINECS: 674-712-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-16 18:36:03
What is 4-Hydroxythiobenzamide?
Chemical properties
4-Hydroxythiobenzamide has an appearance ranging from light orange to yellow to green, powder to crystalline, melting point 192 °C, soluble in methanol.
The Uses of 4-Hydroxythiobenzamide
4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.
The Uses of 4-Hydroxythiobenzamide
febuxostat intermediate
Synthesis
4-Hydroxythiobenzamide is an important intermediate of Febuxostat, a new anti-gout drug. A patent discloses a method for preparing p-hydroxythiobenzamide. Specifically, a certain amount of water, p-cyanophenol, sodium hydrosulfide, and secondary amine are mixed evenly. At a specific temperature, an organic weak acid is added dropwise. After the reaction is completed, the mixture is filtered, and the filter cake is dried to obtain 4-Hydroxythiobenzamide.
Properties of 4-Hydroxythiobenzamide
| Melting point: | 181-185℃ |
| Boiling point: | 320.4±44.0 °C(Predicted) |
| Density | 1.338±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.24±0.26(Predicted) |
| color | Light Yellow |
| InChI | InChI=1S/C7H7NOS/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10) |
| CAS DataBase Reference | 25984-63-8(CAS DataBase Reference) |
Safety information for 4-Hydroxythiobenzamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Hydroxythiobenzamide
| InChIKey | VDTNKXSVUGXUOJ-UHFFFAOYSA-N |
| SMILES | C1(C(N)=S)=CC=C(O)C=C1 |
4-Hydroxythiobenzamide manufacturer
Rivashaa Agrotech Biopharma Pvt. Ltd.
1Y
Phone:+91-7926462688
product: 4-Hydroxythiobenzamide 25984-63-8 98%
Ralington Pharma
1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: 25984-63-8 4-Hydroxythiobenzamide 98%
Samruddhi Agro and Lifescience
1Y
Phone:+91-7028045583
Whatsapp: +91-9923605583
product: 25984-63-8 98%
Apiqule Pharmachem LLP
1Y
Phone:+91-9904897541
Whatsapp: +91-9904897541
product: 4-Hydroxythiobenzamide 99%
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