ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
- CAS NO.:161798-03-4
- Empirical Formula: C18H21NO4S
- Molecular Weight: 347.43
- MDL number: MFCD13194811
- EINECS: 700-743-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-01 17:24:31
What is ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE?
The Uses of ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.
Synthesis
Preparation of Compound of formula III)[0094] A compound of formula II (10.0 gr, 34.33 mmol) was reacted with iso- butyl bromide (18.9 gr, 137.3 mmol) in the presence of potassium carbonate (19.0 gr, 137.3 mmol) and potassium iodide (2.3 gr, 13.7 mmol) in 60 ml dimethylformamide. The reaction was performed at about 70°C during 4 hours. The reaction mixture was extracted at 70°C using 300 ml ethyl acetate and 600 ml water. The separated aqueous phase was washed twice with 100 ml ethyl acetate. The combined organic phase was washed twice with 100 ml water and then concentrated to dryness. The resulting solid residue was re- crystallized from 70 ml ethyl acetate, filtered and dried under reduced pressure at about 40°C to provide a compound of formula III (8.9 gr, yield - 83percent). The Compound of formula III purity is 99.1percent (by HPLC).
Properties of ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
Melting point: | 158-160°C |
Boiling point: | 495.9±55.0 °C(Predicted) |
Density | 1.183 |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) |
pka | 1.39±0.10(Predicted) |
form | Solid |
color | Pale Yellow |
CAS DataBase Reference | 161798-03-4(CAS DataBase Reference) |
Safety information for ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
Computed Descriptors for ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
Abamectin manufacturer
KARPSCHEM LABORATORIES PVT. LTD.
Everest Organics Limited
Rivashaa Agrotech Biopharma Pvt. Ltd.
Ralington Pharma
Prodev Pharma Pvt Ltd
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