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HomeProduct name list4-Fluoro-7-nitrobenzofurazan

4-Fluoro-7-nitrobenzofurazan

Synonym(s):NBD-F

4-Fluoro-7-nitrobenzofurazan Structural

What is 4-Fluoro-7-nitrobenzofurazan?

Chemical properties

BROWN CRYSTALLINE CHUNKS

The Uses of 4-Fluoro-7-nitrobenzofurazan

A fluorescence reagent

The Uses of 4-Fluoro-7-nitrobenzofurazan

4-Chloro-7-nitrobenzofurazan (NBD-chloride) was used in the following studies, Synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamine, Synthesis of functionalized hydroxynaphthofurazan, Spectrophotometric and spectrofluorometric determination of clemastine hydrogen fumarate, loratadine, losartan potassium and ramipril in pharmaceutical formulations. Synthesis of 7-nitrobenzofurazan (NBD)-labeled maleimide, via Diels-Alder reaction. NBD-Cl is widely used to label peptides, proteins, drugs and other biomolecules. It is also a popular derivatizing reagent for HPLC analysis

What are the applications of Application

4-Fluoro-7-nitrobenzofurazan is a fluorescent label

Purification Methods

Purify it by repeated recrystallisation from pet ether (b 40-60o). On treatment with MeONa in MeOH it gives 4-methoxy-7-nitrobenzo-2-oxa-1,3-diazole m 115-116o. [Nunno et al. J Chem Soc (C) 1433 1970.] It is a very good fluorophore for amino acids [Imai & Watanabe Analyt Chim Acta 130 377 1981], as it reacts with primary and secondary amines to form fluorescent adducts with 470nm and 530nm. It gives a glycine derivative with m 185-187o [Miyano et al. Anal Chim ex em Acta 170 81 1985]. 5-Fluorouracil (5 -fluoropyrimidinedi -2,4 -[1 H ,3 H ]-one) [51 -21 -8] M 130.1, m 282 -2 8 3o(dec), 282-286o(dec), pK 1 8.04, pK 2 13.0. Recrystallise it from H2O or MeOH/Et2O and sublime it at 190-200o/0.1mm or 210-230o/0.5mm. UV: at 265-266nm ( 7070). [Barton et al. J Org max Chem 37 329 1972, Duschinsky & Pleven J Am Chem Soc 79 4559 1957, Beilstein 24 III/IV 1229.]

Properties of 4-Fluoro-7-nitrobenzofurazan

Melting point: 52-54 °C(lit.)
Boiling point: 308.6±45.0 °C(Predicted)
Density  1.6753 (estimate)
Flash point: >230 °F
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  It is soluble in DMSO, DMF, CH3OH, CH3CN and CHCl3.
form  Crystalline Chunks
pka -5.59±0.50(Predicted)
color  Brown
BRN  1077571
CAS DataBase Reference 29270-56-2(CAS DataBase Reference)

Safety information for 4-Fluoro-7-nitrobenzofurazan

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 4-Fluoro-7-nitrobenzofurazan

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