Triflumizole
Synonym(s):(E)-4-Chloro-α,α,α-trifluoro-N-(1-imidazol-1-yl-2-propoxyethylidene)-o-toluidine;1-{1-{[4-Chloro-2-(trifluoromethyl)phenyl]imino}-2-propoxyethyl}-1H-imidazole
- CAS NO.:99387-89-0
- Empirical Formula: C15H15ClF3N3O
- Molecular Weight: 345.75
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is Triflumizole?
The Uses of Triflumizole
Triflumizole is used for the control of Gymnospurangum and Venturia spp. in pome fruit, against powdery Erysiphaceae in fruit and vegetables, and against Fusarium, Fulvia and Monilia spp. It is also used as a seed treatment against Helminthospurium, Tilletia and Ustilago spp. in cereals.
Definition
ChEBI: Triflumizole is a carboxamidine resulting from the formal condensation of the amino group of 4-chloro-2-(trifluoromethyl)aniline with the oxygen of the acetyl group of N-(propoxyacetyl)imidazole. A sterol demethylation inhibitor, it is used as a fungicide for the control of powdery mildew, scab and other diseases on a variety of crops. It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is a member of monochlorobenzenes, a member of imidazoles, a member of (trifluoromethyl)benzenes, a carboxamidine, an ether, a conazole fungicide and an imidazole fungicide.
Metabolic pathway
Triflumizole is unstable in aqueous solution when exposed to light and it is readily metabolised by plants and animals. The primary route of metabolism is by cleavage of the imidazole ring to give several metabolites which retain the 4-chloro-2-trifluoromethylaniline moiety. The major metabolite in crops, 2, is formed by loss of the imidazole ring.
Degradation
Aqueous solutions of triflumizole are degraded by sunlight with a DT50 of
29 hours. The sole hydrolysis product of triflumizole in the dark is 2,
which is formed by loss of the imidazole ring.
The major product of photolysis of triflumizole is 4, which is probably
formed in the presence of oxygen via 3. This compound was soluble in the
solid state but decomposed in solution, even if stored in a refrigerator
(Hashimoto et al., 1990).
Properties of Triflumizole
vapor pressure | 1.86 x 10-4 Pa (25 °C ) |
pka | 3.7 (base) |
Water Solubility | 12.5 x 103 mg l-1(20 °C ) |
EPA Substance Registry System | 1H-Imidazole, 1-[(1E)-1-[[4-chloro-2-(trifluoromethyl) phenyl]imino]-2-propoxyethyl]- (99387-89-0) |
Safety information for Triflumizole
Computed Descriptors for Triflumizole
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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