Flusilazole

Chemical properties

Brown-red viscous liquid

The Uses of Flusilazole

Flusilazole is a silicon-containing triazole fungicide. Flusilazole is used to control fungal infections on a variety of fruit and vegetable crops

The Uses of Flusilazole

Agricultural fungicide.

The Uses of Flusilazole

Flusilazole is a broad spectrum fungicide used to control fungal disease caused by pathogens of the Ascomycetes, Basidiomycetes and Deuteromycetes families. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture, horticulture and viticulture. Diseases controlled include eyespot, mildew, and rusts of cereals, cercospora and rust of sugar beets, leaf spots of oilseed rape, scab and mildew of pome and stone fruits, mildew and black rot of grapes and Sigatoka disease of bananas.

Definition

ChEBI: Flusilazole is an organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. It has a role as a xenobiotic, an environmental contaminant, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is a member of monofluorobenzenes, a member of triazoles, an organosilicon compound, a conazole fungicide and a triazole fungicide.

Metabolic pathway

Flusilazole is stable to aqueous hydrolytic and photolytic degradation. Although flusilazole is relatively stable in soil and is detected in plant and animal samples, numerous degradation products have been reported. The primary metabolic pathway involves the cleavage of the methylenesilicon or/and methylene-triazole linkage. Another primary pathway involves aryl hydroxylation followed by conjugation. The primary metabolic/degradation pathways of flusilazole in soil, plant and animals are presented in Scheme 1.

Degradation

Aqueous hydrolysis and photolysis are not sigruficant degradation pathways for flusilazole (1). Flusilazole was stable (<5% decomposition) in sterile buffers at pH 5, 7 and 9 (25 °C) for 34 days (Cadwgan, 1983). No significant degradation was observed when fusilazole was irradiated with simulated sunlight for 30 days at 300-450 nm in sterile buffer solution at pH 7 (Carter, 1986).