4-Aminobenzonitrile

Synonym(s):4-Cyanoaniline

CAS NO.：873-74-5
Empirical Formula: C7H6N2
Molecular Weight: 118.14
MDL number: MFCD00007821
EINECS: 212-850-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-09-20 17:27:21

What is 4-Aminobenzonitrile?

Chemical properties

off-white or beige to orange-yellow crystalline

The Uses of 4-Aminobenzonitrile

4-Aminobenzonitrile is an amino substituted benzonitrile with hypotensive activity. 4-Aminobenzonitrile is used as radioprotective agent

The Uses of 4-Aminobenzonitrile

4-Aminobenzonitrile was used as derivatization reagent in capillary zone electrophoretic analysis of aldoses, ketoses and uronic acid. It was used in the synthesis of methacrylic monomers containing pendant azobenzene structures and polythiophenes containing an azobenzene moiety in the side-chain.

The Uses of 4-Aminobenzonitrile

4-Aminobenzonitrile is used as an amino substituted benzonitrile with hypotensive activity and as a radioprotective agent. It is also used as a derivatization reagent in the capillary zone electrophoretic analysis of aldoses, ketoses and uronic acid. Further, it is used in the preparation of methacrylic monomers containing pendant azobenzene structures and polythiophenes containing an azobenzene moiety in the side-chain.

Antibacterial mechanism

4-Aminobenzonitrile binds with epidermal growth factor (EGF) by intramolecular hydrogen bonding, which leads to the disruption of the protein's tertiary structure.

Purification Methods

It crystallises from water, 5% aqueous EtOH or EtOH and is dried over P2O5 or dried in vacuo for 6hours at 40o. [Moore et al. J Am Chem Soc 108 2257 1986, Edidin et al. J Am Chem Soc 109 3945 1987, Beilstein 14 IV 1158.]

Properties of 4-Aminobenzonitrile

Melting point:	83-85 °C(lit.)
Boiling point:	167 °C / 1mmHg
Density	1.1151 (rough estimate)
vapor pressure	0.002-0.005Pa at 20-25℃
refractive index	1.5500 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka	1.74(at 25℃)
form	Crystalline Powder Chunks
color	Off-white or beige to orange-yellow
Water Solubility	Soluble in ethyl acetate, dichloromethane and chloroform. Insoluble in water.
BRN	774507
Stability:	Toxic
CAS DataBase Reference	873-74-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzonitrile, 4-amino-(873-74-5)
EPA Substance Registry System	Benzonitrile, 4-amino- (873-74-5)

Safety information for 4-Aminobenzonitrile

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H341:Germ cell mutagenicity H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention.