4-Aminobenzonitrile

Chemical properties

off-white or beige to orange-yellow crystalline

The Uses of 4-Aminobenzonitrile

4-Aminobenzonitrile is an amino substituted benzonitrile with hypotensive activity. 4-Aminobenzonitrile is used as radioprotective agent

The Uses of 4-Aminobenzonitrile

4-Aminobenzonitrile was used as derivatization reagent in capillary zone electrophoretic analysis of aldoses, ketoses and uronic acid. It was used in the synthesis of methacrylic monomers containing pendant azobenzene structures and polythiophenes containing an azobenzene moiety in the side-chain.

The Uses of 4-Aminobenzonitrile

4-Aminobenzonitrile is used as an amino substituted benzonitrile with hypotensive activity and as a radioprotective agent. It is also used as a derivatization reagent in the capillary zone electrophoretic analysis of aldoses, ketoses and uronic acid. Further, it is used in the preparation of methacrylic monomers containing pendant azobenzene structures and polythiophenes containing an azobenzene moiety in the side-chain.

Antibacterial mechanism

4-Aminobenzonitrile binds with epidermal growth factor (EGF) by intramolecular hydrogen bonding, which leads to the disruption of the protein's tertiary structure.

Purification Methods

It crystallises from water, 5% aqueous EtOH or EtOH and is dried over P2O5 or dried in vacuo for 6hours at 40o. [Moore et al. J Am Chem Soc 108 2257 1986, Edidin et al. J Am Chem Soc 109 3945 1987, Beilstein 14 IV 1158.]