Phenetidine
Synonym(s):p-Phenetidine;4-Ethoxyaniline
- CAS NO.：156-43-4
- Empirical Formula: C8H11NO
- Molecular Weight: 137.18
- MDL number: MFCD00007865
- EINECS: 205-855-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-28 16:27:48
What is Phenetidine?
Chemical properties
colourless liquid
The Uses of Phenetidine
A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.
Definition
ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 27, p. 347, 1984 DOI: 10.1021/jm00369a019
General Description
Colorless to dark red liquid.
Air & Water Reactions
Very sensitive to exposure to air and light. Turns red to brown on exposure to light and air. . Slightly soluble in water.
Reactivity Profile
Phenetidine reacts vigorously with powerful oxidizers.
Fire Hazard
Phenetidine is combustible.
Safety Profile
Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Properties of Phenetidine
| Melting point: | 2-5 °C(lit.) |
| Boiling point: | 250 °C(lit.) |
| Density | 1.065 g/mL at 25 °C(lit.) |
| vapor pressure | 2.93Pa at 25℃ |
| refractive index | n |
| Flash point: | 240 °F |
| storage temp. | 2-8°C |
| solubility | 20g/l |
| form | A liquid |
| pka | 5.2(at 28℃) |
| color | Clear Yellow |
| PH | 8 (1g/l, H2O, 20℃) |
| Water Solubility | practically insoluble |
| Sensitive | Air Sensitive |
| Merck | 14,7228 |
| BRN | 606666 |
| Dielectric constant | 7.3（21℃） |
| Stability: | Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 156-43-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Ethoxyaniline(156-43-4) |
| EPA Substance Registry System | p-Phenetidine (156-43-4) |
Safety information for Phenetidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Phenetidine
| InChIKey | IMPPGHMHELILKG-UHFFFAOYSA-N |
New Products
Tubulysin B Tubulysin A Tubulysin D (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin F 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE tetrahydro-4-methyl-2H-pyran Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2,2-Difluoropropylamine hydrochloride Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH Fuel shell 5-(piperazin-1-yl) benzofuran-2- carboxamide 1-(4-amino-2- methylbenzoyl)-7- chloro-3,4-dihydro- 1H-benzo[b] azepin-5(2H)-one Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
P-Phenetidine 98% CAS 156-43-4View Details
156-43-4 -
p-Phenetidine CAS 156-43-4View Details
156-43-4 -
p-Phenetidine CAS 156-43-4View Details
156-43-4 -
4-Ethoxyaniline CAS 156-43-4View Details
156-43-4 -
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.