3-Aminobenzoic acid

Synonym(s):3-Aminobenzoic acid

CAS NO.：99-05-8
Empirical Formula: C7H7NO2
Molecular Weight: 137.14
MDL number: MFCD00007795
EINECS: 202-724-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-26 21:18:56

What is 3-Aminobenzoic acid?

Chemical properties

White to off white crystalline powder

The Uses of 3-Aminobenzoic acid

3-Aminobenzoic acid is used as an intermediate for dyes, pesticides and other organic synthesis. It is also used as crystalline Intermediate for azo dyes, pharmaceuticals, and X-ray contrast media.

Preparation

3-Aminobenzoic acid is prepared by the reduction of 3-nitrobenzoic acid and used in dye syntheses. Its derivative N,N-dimethyl-3- aminobenzoic acid is also used in the production of dyes.

Definition

ChEBI: 3-aminobenzoic acid is an aminobenzoic acid carrying an amino group at position 3. It is functionally related to a benzoic acid. It is a conjugate acid of a 3-aminobenzoate.

General Description

3-Aminobenzoic acid, popularly known as Mesalazine Impurity E, is a related compound of anti-inflammatory agent Mesalazine. Mesalazine belongs to a group of drugs referred to as aminosalicylates and is generally used in the treatment of inflammatory bowel disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Crystallise the acid from water. [Beilstein 14 IV 1092.]

Hazard

3-Aminobenzoic acid is irritating to the eyes and skin. Inhalation may cause respiratory irritation and may induce methemoglobinemia.

Properties of 3-Aminobenzoic acid

Melting point:	178-180 °C(lit.)
Boiling point:	251.96°C (rough estimate)
Density	1,51 g/cm³
refractive index	1.5323 (estimate)
Flash point:	150 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	5.9 g/L (15°C)
form	Powder
pka	4.78(at 25℃)
color	White-brownish to beige-brown
Odor	Odorless
Water Solubility	5.9 g/L (15 ºC)
Merck	14,421
BRN	471603
CAS DataBase Reference	99-05-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 3-amino-(99-05-8)
EPA Substance Registry System	Benzoic acid, 3-amino- (99-05-8)

Safety information for 3-Aminobenzoic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up.