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HomeProduct name list3-Amino-4-hydroxybenzoic acid

3-Amino-4-hydroxybenzoic acid

  • CAS NO.:1571-72-8
  • Empirical Formula: C7H7NO3
  • Molecular Weight: 153.14
  • MDL number: MFCD00007697
  • EINECS: 216-390-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
3-Amino-4-hydroxybenzoic acid Structural

What is 3-Amino-4-hydroxybenzoic acid?

Chemical properties

beige-grey to brown crystalline powder

The Uses of 3-Amino-4-hydroxybenzoic acid

3-Amino-4-hydroxybenzoic acid is used to produce 4-acetoxy-3-acetylamino-benzoic acid with acetic acid anhydride at temperature of 0 - 20°C. This reaction will need reagents aq. HCl and NaOAc.

What are the applications of Application

3-Amino-4-hydroxybenzoic acid is the first matrix to be used specifically for carbohydrates. The other most commonly used matrices are α-cyano-4-hydroxycinnamic acid, 2,5-dihydroxybenzoic acid, and sinapinic acid. Matrix and sample solutions are mixed prior to laser exposure, spotted on a solid metallic surface, and allowed to dry before submitting them to MALDI. These matrices are characterized by high absorptivity of the laser radiation and the capability of forming fine crystalline solids during sample/matrix drying. In general, the more fine-grained and homogeneous the morphology of crystals formed with the analyte/matrix mixture, the more intense the MALDI mass spectrum of the analyte. 3-Amino-4-hydroxybenzoic acid produced [M+Na]+ ions from as little as 1 pmol of dextran hydrolysate and N-linked glycans released from glycoproteins.

Definition

ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid carrying an additional amino substitutent at position 3.

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 3740, 1989 DOI: 10.1021/jo00276a044

Properties of 3-Amino-4-hydroxybenzoic acid

Melting point: 208 °C (dec.) (lit.)
Boiling point: 276.03°C (rough estimate)
Density  1.3585 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Soluble in solvents.
pka 9.06±0.18(Predicted)
form  Crystalline Powder
color  Beige-gray to brown
Sensitive  Light Sensitive
λmax 308nm(H2O (pH 11))(lit.)
BRN  972238
InChI InChI=1S/C7H7NO3/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,9H,8H2,(H,10,11)
CAS DataBase Reference 1571-72-8(CAS DataBase Reference)

Safety information for 3-Amino-4-hydroxybenzoic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3-Amino-4-hydroxybenzoic acid

InChIKey MRBKRZAPGUCWOS-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(O)C(N)=C1

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