6-Aminocaproic acid
Synonym(s):ε-Aminocaproic acid;6-Aminocaproic acid;6-Aminohexanoic acid;EACA
- CAS NO.:60-32-2
- Empirical Formula: C6H13NO2
- Molecular Weight: 131.17
- MDL number: MFCD00008238
- EINECS: 200-469-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-24 19:16:04
What is 6-Aminocaproic acid?
Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
The Uses of 6-Aminocaproic acid
6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.
What are the applications of Application
e-Amino-n-caproic Acid is an antifibrinolytic lysine analog shown to inhibit streptokinase and basic carboxypeptidases
Background
An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
Indications
For use in the treatment of excessive postoperative bleeding.
Pharmacokinetics
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity. Aminocaproic acid may be a possible prophylactic for vascular disease, as it may prevent formation of lipoprotein (a), a risk factor for vascular disease.
Metabolism
Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid.
Properties of 6-Aminocaproic acid
Melting point: | 207-209 °C (dec.) (lit.) |
Boiling point: | 242.49°C (rough estimate) |
Density | 1.042 g/cm3 |
Flash point: | 207-209°C |
storage temp. | Store below +30°C. |
solubility | H2O: 50 mg/mL |
form | powder |
color | white |
Odor | Odorless |
Water Solubility | SOLUBLE |
Safety information for 6-Aminocaproic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 6-Aminocaproic acid
InChIKey | SLXKOJJOQWFEFD-UHFFFAOYSA-N |
Abamectin manufacturer
TRC FINE CHEMS
JSK Chemicals
Neugen Labs
Biophore India Pharmaceuticals Pvt Ltd
Optimus Pharma Pvt Ltd (Sekhmet Pharmaventures))
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