β-Elemonic Acid
- CAS NO.：28282-25-9
- Empirical Formula: C30H46O3
- Molecular Weight: 454.68
- MDL number: MFCD32661885
- EINECS: 300-005-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is β-Elemonic Acid?
Description
β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 μM) in vitro. β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 μM) in vitro.
The Uses of β-Elemonic Acid
β-Elemonic Acid inhibits cell proliferation of human lung adenocarcinoma A549 cells and role of MAPK, ROS activation and glutathione depletion. Elemonic acid is also a Pin1 inhibitors.
Properties of β-Elemonic Acid
| Melting point: | 224-225°C |
| Boiling point: | 565.2±50.0 °C(Predicted) |
| Density | 1.07 |
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml |
| form | A crystalline solid |
| pka | 4.65±0.10(Predicted) |
| color | White to off-white |
Safety information for β-Elemonic Acid
Computed Descriptors for β-Elemonic Acid
New Products
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