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HomeProduct name listβ-Elemonic Acid

β-Elemonic Acid

  • CAS NO.:28282-25-9
  • Empirical Formula: C30H46O3
  • Molecular Weight: 454.68
  • MDL number: MFCD32661885
  • EINECS: 300-005-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
β-Elemonic Acid Structural

What is β-Elemonic Acid?

Description

β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 μM) in vitro. β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 μM) in vitro.

The Uses of β-Elemonic Acid

β-Elemonic Acid inhibits cell proliferation of human lung adenocarcinoma A549 cells and role of MAPK, ROS activation and glutathione depletion. Elemonic acid is also a Pin1 inhibitors.

Properties of β-Elemonic Acid

Melting point: 224-225°C
Boiling point: 565.2±50.0 °C(Predicted)
Density  1.07
storage temp.  2-8°C
solubility  DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml
form  A crystalline solid
pka 4.65±0.10(Predicted)
color  White to off-white

Safety information for β-Elemonic Acid

Computed Descriptors for β-Elemonic Acid

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