3-(2-Pyrrolidinyl)pyridine
Synonym(s):(±)-Nornicotine;2-(3-Pyridyl)pyrrolidine;3-(2-Pyrrolidinyl)pyridine
- CAS NO.:5746-86-1
- Empirical Formula: C9H12N2
- Molecular Weight: 148.21
- MDL number: MFCD00016913
- EINECS: 637-353-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-07 19:09:42
What is 3-(2-Pyrrolidinyl)pyridine?
Description
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 μM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine.
Chemical properties
Colourless Oil
The Uses of 3-(2-Pyrrolidinyl)pyridine
A metabolite of Nicotine ((N412420). Can catalyze aqueous aldol reactions.
The Uses of 3-(2-Pyrrolidinyl)pyridine
3-(2-Pyrrolidinyl)pyridine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).
The Uses of 3-(2-Pyrrolidinyl)pyridine
A metabolite of Nicotine. Can catalyze aqueous aldol reactions
What are the applications of Application
(R,S)-Nornicotine is a metabolite of Nicotine
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 1137, 1996 DOI: 10.1016/0040-4039(96)00002-0
Safety Profile
Poison by intraperitoneal route.When heated to decomposition it emits very toxic fumesof NOx and HCl. See also NORNICOTINE
Properties of 3-(2-Pyrrolidinyl)pyridine
Melting point: | 235-236 °C(Solv: ethanol (64-17-5)) |
Boiling point: | 107-108°C 2mm |
Density | 1,074 g/cm3 |
refractive index | 1.54 |
Flash point: | 101°C |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL |
form | liquid |
pka | 9.09±0.10(Predicted) |
Specific Gravity | 1.074 |
color | yellow |
Water Solubility | Soluble in acetone, chloroform and water (50mg/ml). |
Merck | 14,6712 |
BRN | 81968 |
Stability: | Hygroscopic, Light Sensitive, Moisture Sensitive |
CAS DataBase Reference | 5746-86-1(CAS DataBase Reference) |
Safety information for 3-(2-Pyrrolidinyl)pyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-(2-Pyrrolidinyl)pyridine
New Products
2,2-diethoxyethanethioamide Tubulysin M Tubulysin E (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Diethyl Aluminium Cyanide (1.0 M in Toluene) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 4,4-DIFLUOROPIPERIDINE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2H-Pyran, 4-ethynyltetrahydro- 2,2-Difluoropropylamine hydrochloride 3-N-BOC-(S)-AMINO BUTYRONITRILE (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
(±)-Nornicotine solution CAS 5746-86-1View Details
5746-86-1 -
Nicotine Related Compound F CAS 5746-86-1View Details
5746-86-1 -
(±)-Nornicotine CAS 5746-86-1View Details
5746-86-1 -
Nicotine Related Compound F CAS 5746-86-1View Details
5746-86-1 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8