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HomeProduct name list2,4,5-Trichlorophenoxyacetic acid

2,4,5-Trichlorophenoxyacetic acid

Synonym(s):2,4,5-T;2,4,5-Trichlorophenoxyacetic acid;Trioxone

  • CAS NO.:93-76-5
  • Empirical Formula: C8H5Cl3O3
  • Molecular Weight: 255.48
  • MDL number: MFCD00004301
  • EINECS: 202-273-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-20 14:22:13
2,4,5-Trichlorophenoxyacetic acid Structural

What is 2,4,5-Trichlorophenoxyacetic acid?

Chemical properties

white to light tan odourless solid

Chemical properties

2,4,5-T Acid is an odorless, colorless to tan crystalline solid.

Physical properties

Colorless to pale brown, odorless crystals. Odor threshold from water is 2.92 mg/kg (quoted, Keith and Walters, 1992). Metallic taste.

The Uses of 2,4,5-Trichlorophenoxyacetic acid

It is suitable for plant cell culture tested. Post-emergence herbicide.

The Uses of 2,4,5-Trichlorophenoxyacetic acid

Plant hormone; defoliant; herbicide used to control undesirable brush and woody plants.

The Uses of 2,4,5-Trichlorophenoxyacetic acid

2,4,5-T was formerly used as a herbicide. Itis currently not used, following a ban by theEPA.

Definition

ChEBI: A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2, 4 and 5 are substituted by chlorines.

General Description

Light tan solid (melting point 153°C). Insoluble in water. Contact may irritate the skin.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,4,5-Trichlorophenoxyacetic acid is a weak acid. Reacts with organic and inorganic bases to form water-soluble salts and with alcohols to form esters. Incompatible with strong oxidizing agents and strong bases. Can corrode metals, especially if moist. May harm painted surfaces .

Health Hazard

Overexposure to dust by inhalation or ingestion may cause fatigue, nausea, vomiting, lowered blood pressure, convulsions, coma. Dust may irritate eyes and skin.

Health Hazard

The toxicity of 2,4,5-T is very similar tothat of 2,4-D. The symptoms are irritationof skin, acne-like rash, somnolence, gastritis,fatty liver degeneration, and ataxia.
LD50 value, oral (rats): 300 mg/kg
Oral administration of this compound inhamsters and mice produced fetotoxicity,as well as developmental toxic effects onthe central nervous system, eyes, ear, andprostate.

Fire Hazard

Special Hazards of Combustion Products: Toxic hydrogen chloride and phosgene gases may be formed.

Potential Exposure

Those engaged in the manufacture, formulation, and application of this herbicide used to control woody and herbaceous weeds. The EPA has issued a rebuttable presumption against registration of 2,4,5-T for pesticide uses, however. The Viet Nam war era defoliant, Agent Orange, was a mixture of 2,4,5-T and 2,4-D.

Carcinogenicity

2,4,5-T was not mutagenic in bacterial assays, and it did not induce aneuploidy or somatic mutation in vitro. In vivo it did not cause micronuclei in mice or dominant lethal mutations in mice or rats.

Environmental Fate

Biological. 2,4,5-T degraded in anaerobic sludge by reductive dechlorination to 2,4,5- trichlorophenol, 3,4-dichlorophenol and 4-chlorophenol (Mikesell and Boyd, 1985). An anaerobic methanogenic consortium, growing on 3-chlorobenzoate, metabolized 2,4,5-T to (2,5-dichlorophenoxy)acetic acid at a rate of 1.02 × 10–7 M/hr. The half-life was reported to be 2 days at 37°C (Su?ita et al., 1984). Under aerobic conditions, 2,4,5-T degraded to 2,4,5- trichlorophenol and 3,5-dichlorocatechol which may further degrade to 4-chlorocatechol or cis,cis-2,4-dichloromuconic acid, 2-chloro-4-carboxymethylenebut-2-enolide, chlorosuccinic acid and succinic acid (Byast and Hance, 1975). The cometabolic oxidation of 2,4,5-T by Brevibacterium sp. yielded a product tentatively identified as 3,5-dichlorocatechol (Horvath, 1970). The cometabolism of this compound by Achromobacter sp. gave 3,5-dichloro-2- hydroxymuconic semialdehyde (Horvath, 1970a). Rosenberg and Alexander (1980) reported that 2,4,5-trichlorophenol, the principal degradation product of 2,4,5-T by microbes, was further metabolized to 3,5-dichlorocatechol, 4-chlorocatechol, succinate, cis,cis-2,4-dichlo- romuconate, 2-chloro-4-(carboxymethylene)but-2-enolide and chlorosuccinate.
Soil. 2,4,5-Trichlorophenol and 2,4,5-trichloroanisole were the primary degradation products formed when 2,4,5-T was incubated in soil at 25°C under aerobic conditions. The half-life under these conditions was 14 days (McCall et al., 1981a). When
The half-lives of 2,4,5-T in soil incubated in the laboratory under aerobic conditions ranged from 14 to 64 days with an average of 33 days (Altom and Stritzke, 1973; Foster and McKercher, 1973; Yoshida and Castro, 1975). In field soils, the disappearance
Groundwater . According to the U.S. EPA (1986) 2,4,5-T has a high potential to leach to groundwater .
Photolytic. When 2,4,5-T (10–4 M) in oxygenated water containing titanium dioxide (2 g/L) suspension was irradiated by sunlight (λ ≥340 nm), 2,4,5-trichlorophenol, 2,4,5- trichlorophenyl formate and nine chlorinated aromatic hydrocarbons formed a

Solubility in water

Soluble in ethanol (548.2 mg/L), ether (243.2 mg/L), heptane (400 mg/L), xylenes (6.8 g/L), methanol (496 g/L), toluene (7.32 g/L) (quoted, Keith and Walters, 1992).

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3345 Phenoxyacetic acid derivative pesticide, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Crystallise this herbicide from *benzene. [Beilstein 6 III 721.] (CANCER SUSPECT)

Incompatibilities

The aqueous solution is a weak acid. Incompatible with sulfuric acid, bases, ammonia, aliphatic amines; alkanolamines, isocyanates, alkylene oxides; epichlorohydrin; strong oxidizers, such as chlorine, bromine, fluorine, and strong bases.

Waste Disposal

Two disposal procedures have been discussed for 2,4,5-T: (1) Mix with excesssodium carbonate, add water and let stand for 24 hours before flushing down the drain with excess water; and (2) pour onto vermiculite and incinerate with wood, paper, and waste alcohol. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Properties of 2,4,5-Trichlorophenoxyacetic acid

Melting point: 154-158 °C(lit.)
Boiling point: 361.82°C (rough estimate)
Density  1.6048 (rough estimate)
vapor pressure  6.46 at 25 °C (Lewis, 1989)
refractive index  1.4700 (estimate)
Flash point: 2 °C
storage temp.  0-6°C
solubility  Soluble in ethanol (548.2 mg/L), ether (243.2 mg/L), heptane (400 mg/L), xylenes (6.8 g/L), methanol (496 g/L), toluene (7.32 g/L) (quoted, Keith and Walters, 1992).
form  crystalline
pka 2.80 and 2.83 at 25 °C (ionic strength <0.01 M, Jafvert et al., 1990)
2.88 (Nelson and Faust, 1969)
color  off-white to yellow
Water Solubility  238mg/L(20 ºC)
Merck  13,9111
Henry's Law Constant 4.87 at 25 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits NIOSH REL: TWA 10 mg/m3, IDLH 250 mg/m3; OSHA PEL: TWA 10 mg/m3; ACGIH TLV: TWA 10 mg/m3.
Stability: Stable. Incompatible with strong bases, strong oxidizing agents, alkali metals, amines, alcohols. Reacts with many common metals.
CAS DataBase Reference 93-76-5(CAS DataBase Reference)
NIST Chemistry Reference Acetic acid, 2,4,5-trichlorophenoxy-(93-76-5)
EPA Substance Registry System 2,4,5-T (93-76-5)

Safety information for 2,4,5-Trichlorophenoxyacetic acid

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Environment
GHS09
GHS Hazard Statements H301:Acute toxicity,oral
H312:Acute toxicity,dermal
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2,4,5-Trichlorophenoxyacetic acid

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