(Trifluoromethoxy)benzene

Synonym(s):α,α,α-Trifluoroanisole;Phenyl trifluoromethyl ether

CAS NO.：456-55-3
Empirical Formula: C7H5F3O
Molecular Weight: 162.11
MDL number: MFCD00040832
EINECS: 207-269-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is (Trifluoromethoxy)benzene?

Chemical properties

Colorless to light yellow liqui

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 1, 1964 DOI: 10.1021/jo01024a001

General Description

(Trifluoromethoxy)benzene is an aryl trifluoromethyl ether. (Trifluoromethoxy)benzene can be prepared from 4-chloro-1-(trifluoromethoxy)benzene via hydrogenolysis. Conformation of (trifluoromethoxy)benzene in the gas phase has been studied by electron diffraction and spectroscopy supplemented with ab initio calculations.

Properties of (Trifluoromethoxy)benzene

Melting point:	-49.9°C
Boiling point:	102 °C(lit.)
Density	1.226 g/mL at 25 °C(lit.)
vapor pressure	41.3 mm Hg ( 25 °C)
refractive index	n20/D 1.406(lit.)
Flash point:	54 °F
storage temp.	Sealed in dry,2-8°C
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	1.226
BRN	2043132
CAS DataBase Reference	456-55-3(CAS DataBase Reference)
NIST Chemistry Reference	Trifluoromethoxybenzene(456-55-3)
EPA Substance Registry System	(Trifluoromethoxy)benzene (456-55-3)

Safety information for (Trifluoromethoxy)benzene

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.