2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

Synonym(s):5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII;PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem

CAS NO.：6318-41-8
Empirical Formula: C11H7NO4S
Molecular Weight: 249.24
MDL number: MFCD18382117
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-15 19:19:13

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Structural

What is 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-?

Description

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC₅₀ = 70 nM), compared to PI3Kα (IC₅₀ = 240 nM), PI3Kβ (IC₅₀ = 1.45 μM), and PI3Kδ (IC₅₀ =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED₅₀ = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

References

1) Ferrandi et al. (2007) Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment: J. Pharmacol. Exp. Ther. 322 923

Properties of 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

Density	1.595±0.06 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	Soluble in DMSO (up to 25 mg/ml).
form	Yellow solid
pka	7.13±0.20(Predicted)
color	Yellow
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.