PI3-Kinase α Inhibitor 2
- CAS NO.：371943-05-4
- Empirical Formula: C16H15N3O2S
- Molecular Weight: 313.37
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is PI3-Kinase α Inhibitor 2?
Description
PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC50 = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 μM.
What are the applications of Application
Compound 15e is a potent inhibitor of the PI 3-kinase p110α isoform
Definition
ChEBI: PI3-Kinase alpha Inhibitor 2 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and an organic heterobicyclic compound.
Properties of PI3-Kinase α Inhibitor 2
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMF:PBS(pH 7.2) (1:3): 0.25mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml |
| form | White to off-white solid. |
Safety information for PI3-Kinase α Inhibitor 2
Computed Descriptors for PI3-Kinase α Inhibitor 2
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