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HomeProduct name list2,3-Diaminobenzoic acid

2,3-Diaminobenzoic acid

  • CAS NO.:603-81-6
  • Empirical Formula: C7H8N2O2
  • Molecular Weight: 152.15
  • MDL number: MFCD00137818
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-25 16:21:11
2,3-Diaminobenzoic acid Structural

What is 2,3-Diaminobenzoic acid?

The Uses of 2,3-Diaminobenzoic acid

2,3-Diaminobenzoic acid (23DBA) is an important organic reagent mainly used in scientific research and laboratory experiments. 23DBA can undergo polycondensation with terephthalic acid dichloro anhydride[1]. 23DBA isomer is also used in the study of luminescence mechanism of red luminescent carbon dots (RCDs)[2]. In addition, 2,3-Diaminobenzoic acid also possesses antioxidant properties that help reduce the formation of free radicals in the body. It is also used as a chelating agent that effectively binds to metal ions and prevents them from forming insoluble complexes.

What are the applications of Application

2,3-Diaminobenzoic acid is an aromatic building block

Synthesis

2,3-Diaminobenzoic acid is synthesised using 3-nitroanthranilic acid as a raw material by chemical reaction. The specific synthesis steps are as follows:
2-amino-3-nitrobenzoic acid (9.36 g, 51.4 mmol) was dissolved in MeOH (100 mL) and there was added 10% Pd/C (2.0g). The reaction was stirred under H2-atmosphere (ambient pressure) until absorption ceased. The reaction was filtered through a pad of Celite and the filtrate was evaporated under reduced pressure. The product was purified by flash chromatography (CH2Cl2/MeOH 5:1) and the collected fractions were evaporated to give 2,3-Diaminobenzoic acid (5.40 g, 69%) as a dark brown solid. mp. 199 °C dec. (Litt4. 201 °C dec.). 1H NMR (300 MHz, DMSO-d6) δ 7.09 (dd, J = 8.0, 1.5 Hz, 1H), 6.67 (dd, J = 7.4, 1.5 Hz, 1H), 6.34 (dd, J = 8.0, 7.4 Hz, 2H), 6.32 (br s, 4H). 13C NMR (75 MHz, DMSO-d6) δ 170.5, 139.6, 135.6, 119.4, 117.0, 114.9, 110.3.
2,3-Diaminobenzoic acid synthesis

References

[1] V. N. ODNORALOVA. The polycondensation reaction of 2,4-diaminobenzoic acid with dichloroanhydride of terephthalic acid[J]. Fibre Chemistry, 1974. DOI:10.1007/BF00542946.
[2] LIU Y, DING H, ZHANG S, et al. Photoluminescence mechanism of red emissive carbon dots from a diaminobenzoic acid isomer?[J]. Materials Advances, 2023. DOI:10.1039/D3MA00836C.

Properties of 2,3-Diaminobenzoic acid

Melting point: 198-204 °C
Boiling point: 274.61°C (rough estimate)
Density  1.2804 (rough estimate)
refractive index  1.5200 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
pka 5.10±0.10(Predicted)
form  solid
color  Brown to dark brown
CAS DataBase Reference 603-81-6(CAS DataBase Reference)

Safety information for 2,3-Diaminobenzoic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 2,3-Diaminobenzoic acid

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