Benzocaine
Synonym(s):4-Aminobenzoic acid ethyl ester;Benzocainum;Ethyl 4-aminobenzoate
- CAS NO.:94-09-7
- Empirical Formula: C9H11NO2
- Molecular Weight: 165.19
- MDL number: MFCD00007892
- EINECS: 202-303-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-18 08:51:57
What is Benzocaine?
Toxicity
Patients experiencing an overdose may present with local anesthetic systemic toxicity syndrome, decreased cardiovascular function, decreased central nervous system function, cardiac arrest, bradycardia, hypotension, cardiac arrhythmias, syncope, and seizures. Patients should be treated with symptomatic and supportive measures which include airway maintenance, controlling seizures, and hemodynamic stabilization.
Description
Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or
phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and
lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites,
toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters.
Benzocaine is a lipophilic local anesthetic agent with a short duration of action.
Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase.
Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind
to the lipid side of the local anesthetic receptor. It also can easily cross membranes
into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it
has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial
agents.
Description
Benzocaine, a common ingredient in sunburn remedies and first aid creams, is a topical anesthetic—it numbs the nerve endings near the surface of the skin where it is applied. This ethyl ester of?p-aminobenzoic acid (PABA, a common sunscreen ingredient) can react with compounds in sunscreens and hair dyes or produce an allergic reaction.
The Uses of Benzocaine
Benzocaine is used as an anesthetic (Local and topical) that in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.
Background
Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products. Benzocaine was first used for local anesthesia in dentistry.
Indications
Benzocaine is indicated for local anesthesia in dentistry, minor trauma, and as preparation for infiltrative anesthesia. Benzocaine products are indicated for topical anesthesia in a wide variety of conditions including skin irritation, oral pain, and hemorrhoids.
What are the applications of Application
Benzocaine is a surface anesthetic
Pharmacokinetics
Benzocaine is indicated for use as a topical anesthetic. It has a duration of action of approximately 10 minutes and a wide therapeutic window. Patients should be counselled regarding the risks of methemoglobinemia.
Metabolism
Benzocaine undergoes ester hydrolysis to form 4-aminobenzoic acid, acetylation to form acetylbenzocaine, or N-hydroxylation to form benzocaine hydroxide. 4-aminobenzoic acid can be acetylated or acetylbenzocaine can undergo ester hydrolysis to form 4-acetaminobenzoic acid.
Properties of Benzocaine
Melting point: | 88-90 °C |
Boiling point: | 172 °C (12.7517 mmHg) |
Density | 1.17 |
Flash point: | 172°C/13mm |
storage temp. | 2-8°C |
solubility | alcohol: soluble1 gm in 5 ml |
form | Crystalline Powder |
color | White |
Water Solubility | Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water |
Safety information for Benzocaine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H317:Sensitisation, Skin |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
Computed Descriptors for Benzocaine
InChIKey | BLFLLBZGZJTVJG-UHFFFAOYSA-N |
Abamectin manufacturer
NB Healthcare Pvt Ltd
REDDY N REDDY PHARMACEUTICALS
JSK Chemicals
Dishman Carbogen Amcis Ltd (Dishman Group)
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