2-Aminocyclohexanol
- CAS NO.:6850-38-0
- Empirical Formula: C6H13NO
- Molecular Weight: 115.17
- MDL number: MFCD00191368
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:37
What is 2-Aminocyclohexanol?
Chemical properties
White to Light orange to Yellow powder to crystal.
The Uses of 2-Aminocyclohexanol
Trans-2-aminocyclohexanol and cis-/trans-1,2-cyclohexanediamines have found their application in the synthesis of the antiarrhythmic medicament vernakalant and spleen tyrosine kinase inhibitor, κ-opioid analgesics.
Preparation
2-Aminocyclohexanol Synthesis: Under water bath reaction conditions, 214.3 g of ammonia water was added to a 500 mL three-necked flask. Stir and heat, and when the internal temperature reaches about 50°C, start to slowly drop 50.0 g of 1,2-epoxycyclohexane into the reaction flask. After the dropwise addition was completed, the reaction was performed at a constant temperature for 12h. After the reaction was completed, the reaction was processed to obtain a crude product, which was purified by recrystallization to obtain 2-aminocyclohexanol with a yield of 90% and an amine value (mgKOH/g) of 453.
Properties of 2-Aminocyclohexanol
Melting point: | 65 °C |
Boiling point: | 212 °C |
Density | 1.037±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | soluble in Methanol |
form | powder to crystal |
pka | 14.94±0.40(Predicted) |
color | White to Light orange to Yellow |
CAS DataBase Reference | 6850-38-0(CAS DataBase Reference) |
Safety information for 2-Aminocyclohexanol
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-Aminocyclohexanol
InChIKey | PQMCFTMVQORYJC-UHFFFAOYSA-N |
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