1-Bromopentane

Synonym(s):n-Amyl bromide;Pentyl bromide

CAS NO.：110-53-2
Empirical Formula: C5H11Br
Molecular Weight: 151.04
MDL number: MFCD00000267
EINECS: 203-776-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 1-Bromopentane?

Chemical properties

liquid

The Uses of 1-Bromopentane

1-Bromopentane is a chemical reagent used in a multitude of organic syntheses. It is used iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling. It is used in the synthesis of α, γ-diketo acids as reversible inhibitors of Hepatitis C virus NS5b RNA polymerase.

The Uses of 1-Bromopentane

1-Bromopentane is used in a multitude of organic synthesis. It is used in iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling.

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 5037, 1964 DOI: 10.1021/ja01076a084

General Description

1-Bromopentane undergoes phase transfer catalysed alkylation reaction with 2′-hydroxy acetophenone using tetrabutyl ammonium bromide as catalyst.

Safety Profile

Moderately toxic byintraperitoneal route. Slightly toxic by inhalation. Whenheated to decomposition it emits toxic vapors of Br^-.

Purification Methods

Wash the bromide with conc H2SO4, then water, 10% Na2CO3 solution, again with water, dry with CaCl2 or K2CO3, and fractionally distil it just before use. [Beilstein 1 IV 312.]

Properties of 1-Bromopentane

Melting point:	−95 °C(lit.)
Boiling point:	130 °C(lit.)
Density	1.218 g/mL at 25 °C(lit.)
vapor density	>1 (vs air)
refractive index	n20/D 1.444(lit.)
Flash point:	88 °F
storage temp.	Flammables area
solubility	H2O: insoluble
form	Liquid
color	Clear colorless to light yellow
Water Solubility	practically insoluble
Merck	14,602
BRN	1730981
Dielectric constant	6.3（10℃）
Stability:	Stable. Flammable. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference	110-53-2(CAS DataBase Reference)
NIST Chemistry Reference	Pentane, 1-bromo-(110-53-2)
EPA Substance Registry System	Pentane, 1-bromo- (110-53-2)

Safety information for 1-Bromopentane

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water.