Z-Vad-fmk, non-methylated

Synonym(s):Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem;Z-VAD-FMK

CAS NO.：161401-82-7
Empirical Formula: C21H28FN3O7
Molecular Weight: 453.46
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Z-Vad-fmk, non-methylated?

Description

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use.

General Description

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.

Biochem/physiol Actions

Product does not compete with ATP.

Properties of Z-Vad-fmk, non-methylated

Boiling point:	758.0±60.0 °C(Predicted)
Density	1.260±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
form	Off-white solid
pka	3.91±0.19(Predicted)
color	White to light yellow

Safety information for Z-Vad-fmk, non-methylated

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.