Z-DEVD-FMK
Synonym(s):Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem;Z-D(OMe)E(Ome)VD(OMe)-FMK
- CAS NO.:210344-95-9
- Empirical Formula: C30H41FN4O12
- Molecular Weight: 668.66
- MDL number: MFCD23380217
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-11 17:44:06
What is Z-DEVD-FMK?
The Uses of Z-DEVD-FMK
Z-DEVD-FMK is an irrversible caspase-3 inhibitor used as an anaesthetic agent. In addition, it is proposed to increase the longevity of platelet storage.
What are the applications of Application
Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
What are the applications of Application
Z-DEVD-FMK is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
Definition
ChEBI: Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent.
General Description
A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 μg/75 μl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
Biological Activity
Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo .
Biochem/physiol Actions
Cell permeable: yes
References
1. garcia-calvo m, peterson ep, leiting b, ruel r, nicholson dw, thornberry na (1998) inhibition of human caspases by peptidebased and macromolecular inhibitors. j biol chem 273:32608–32613 2. thornberry na, rano ta, peterson ep, rasper dm, timkey t, garcia-calvo m, houtzager vm, nordstrom pa, roy s, vaillancourt jp, chapman kt, nicholson dw (1997) a combinatorial approach defines specificities of members of the caspase family and granzyme b. functional relationships established for key mediators of apoptosis. j biol chem 272:17907–17911 3. yakovlev ag, knoblach sm, fan l, fox gb, goodnight r, faden ai (1997) activation of cpp32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. j neurosci 17:7415–7424 4. clark rs, kochanek pm, watkins sc, chen m, dixon ce, seidberg na, melick j, loeffert je, nathaniel pd, jin kl, graham sh (2000) caspase-3 mediated neuronal death after traumatic brain injury in rats. j neurochem 74:740–753 5. s. m. knoblach, d. a. alroy et al, caspase inhibitor z-devd-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury, journal of cerebral blood flow & metabolism 24:1119–1132.
Properties of Z-DEVD-FMK
Boiling point: | 914.2±65.0 °C(Predicted) |
Density | 1.260±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO/DMF: ≥20 mM |
form | White to slightly brown solid |
pka | 10.26±0.46(Predicted) |
color | White to off-white |
Safety information for Z-DEVD-FMK
Computed Descriptors for Z-DEVD-FMK
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION XANTHAN GUM Racecadotril SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Folic Acid Impurity G Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
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