CASPASE-8 INHIBITOR II
Synonym(s):Z-IETD-FMK
- CAS NO.:210344-98-2
- Empirical Formula: C30H43FN4O11
- Molecular Weight: 654.68
- MDL number: MFCD03490491
- Update Date: 2024-11-19 23:02:33
What is CASPASE-8 INHIBITOR II?
The Uses of CASPASE-8 INHIBITOR II
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.
What are the applications of Application
Caspase-8 inhibitor II is a potent, cell permeable, and irreversible inhibitor of caspase-8 and granzyme B
Biological Activity
z-ietd-fmk is an inhibitor of caspase 8 [1].z-ietd-fmk inhibits t cell proliferation induced by pha or anti-cd3 plus anti-cd28 without toxicity of resting t cells. the mechanism of this inhibition of z-ietd-fmk has been proved not through the effect on il-2 secretion or ifn-γ production but the decrease of cd25 expression. experiments show that z-ietd-fmk has no effect on normal cell growth when there is no activation signal. z-ietd-fmk has also been found to significantly inhibit nf-κb activation when the concentration is 100μm [1].apart from the ability of inhibiting cell proliferation, z-ietd-fmk is reported to inhibit trail-mediated killing in cells. it protects the procaspases 9, 2, and 3, and protects parp to a similar extent in both hct116 and sw480 cells [2].
References
[1] c.p. lawrence, s.c. chow. suppression of human t cell proliferation by the caspase inhibitors, z-vad-fmk and z-ietd-fmk is independent of their caspase inhibition properties. toxicology and applied pharmacology. 2012, 265: 103-112.
[2] nesrin özören, kunhong kim, timothy f. burns, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer research. 2000, 60: 6259-6265.
Properties of CASPASE-8 INHIBITOR II
Boiling point: | 925.7±65.0 °C(Predicted) |
Density | 1.247±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Soluble in DMSO |
form | Powder |
pka | 11.12±0.46(Predicted) |
color | White to light yellow |
Safety information for CASPASE-8 INHIBITOR II
Computed Descriptors for CASPASE-8 INHIBITOR II
New Products
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