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HomeProduct name listY16

Y16

Synonym(s):4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione

  • CAS NO.:429653-73-6
  • Empirical Formula: C24H20N2O3
  • Molecular Weight: 384.43
  • MDL number: MFCD03083787
  • Update Date: 2024-11-09 21:40:10
Y16 Structural

What is Y16?

Biological Activity

Y16 is an inhibitor of G protein-coupled Rho GEFs. It blocks the binding of LARG and Rho with a Kd of 80 nM.

in vitro

Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours ; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.

Cell Viability Assay

Cell Line: NIH 3T3 cells
Concentration: 10 μΜ, 30 μΜ
Incubation Time: 24 hours
Result: Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA.

Western Blot Analysis

Cell Line: NIH 3T3 cells
Concentration: 10 μΜ, 30 μΜ
Incubation Time: 24 hours
Result: Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA.

Properties of Y16

Density  1.273±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: soluble5mg/mL, clear (warmed)
pka 8.84±0.20(Predicted)
form  powder
color  , faint yellow to dark orange

Safety information for Y16

Computed Descriptors for Y16

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