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HomeProduct name listCTS-1027

CTS-1027

CTS-1027 Structural

What is CTS-1027?

Biological Activity

CTS-1027 is a potent MMP inhibitor with IC50 values of 0.3 nM and 0.5 nM for MMP2 and MMP13, respectively.

in vivo

CTS-1027 significantly reduces the hepatocyte apoptosis, features of cholestatic liver injury, amd markers of hepatic fibrogenesis in the BDL mouse. It improves overall animal survival following 14 days of BDL in mice. In male animals treated for 8 weeks the terminal plasma concentration of RS-130830 is 311±45 nM. Treatment of male mice with RS-130830 for 8 weeks causes an 89% increase in plasma triglyceride concentration, but there is no corresponding effect in female mice treated for 12 Plaque. The lipid content of animals receiving RS-130830 is increased by 81% at 12 weeks, and increased by 41% at 16 weeks.

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Properties of CTS-1027

Density  1.388±0.06 g/cm3(Predicted)
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  Soluble in DMSO
pka 9.27±0.23(Predicted)
form  A solid
color  White to off-white

Safety information for CTS-1027

Computed Descriptors for CTS-1027

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