XL-388
Synonym(s):[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone;XL-388
- CAS NO.：1251156-08-7
- Empirical Formula: C23H22FN3O4S
- Molecular Weight: 455.5
- MDL number: MFCD24386875
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:46
What is XL-388?
The Uses of XL-388
XL388 is a highly potent, orally bioavailable, selective, ATP-competitive mammalian target of rapamycin (mTOR) inhibitor. XL388 has shown significant and dose-dependent antitumor activity in athymic nude mice implanted with human tumor xenografts.
Properties of XL-388
| Melting point: | >188oC (dec.) |
| Boiling point: | 738.6±60.0 °C(Predicted) |
| Density | 1.354±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 6.22±0.13(Predicted) |
| color | Off-White to Pale Yellow |
| Stability: | Hygroscopic |
Safety information for XL-388
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for XL-388
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