Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listOSI-027

OSI-027

OSI-027 Structural

What is OSI-027?

Description

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of mTOR and, as a result, inhibits both mTORC1 and mTORC2 (IC50s = 22 and 65 nM, respectively). It is selective for mTOR over phosphatidylinositol 3-kinase isoforms and DNA protein kinase. OSI-027 prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 μM. OSI-027 is effective in vivo, blocking the phosphorylation of targets of mTORC1 and mTORC2 and suppressing tumor growth in several different human xenograft models.

The Uses of OSI-027

OSI-027 is a kinase inhibitor with anti-tumor activity, used in treatment of breast cancer.

What are the applications of Application

OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor

Definition

ChEBI: 4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-cyclohexanecarboxylic acid is a member of indoles.

References

[1] bhagwat s v, gokhale p c, crew a p, et al. preclinical characterization of osi-027, a potent and selective inhibitor of mtorc1 and mtorc2: distinct from rapamycin. molecular cancer therapeutics, 2011, 10(8): 1394-1406.

Properties of OSI-027

Melting point: >149°C (subl.)
Density  1.59
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly)
form  Solid
pka 4.44±0.10(Predicted)
color  Pale Beige to Light Beige

Safety information for OSI-027

Computed Descriptors for OSI-027

Related products of tetrahydrofuran

You may like

  • OSI-027 >95% CAS 936890-98-1
    OSI-027 >95% CAS 936890-98-1
    936890-98-1
    View Details
  • 446292-08-6 (S)-2-{2-Oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-isoindole-1,3-dione 99
    446292-08-6 (S)-2-{2-Oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-isoindole-1,3-dione 99
    446292-08-6
    View Details
  • Iminostilbene 256-96-2 98
    Iminostilbene 256-96-2 98
    256-96-2
    View Details
  • 147403-52-9 > 99
    147403-52-9 > 99
    147403-52-9
    View Details
  • 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride 120013-39-0 > 99.0
    5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride 120013-39-0 > 99.0
    120013-39-0
    View Details
  • 718635-93-9 3-(dimethylamino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one >99%
    718635-93-9 3-(dimethylamino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one >99%
    718635-93-9
    View Details
  • 120014-30-4 5,6-Dimethoxy-2-[(4-piperidyl) methyl]indan-1-one > 99.0
    120014-30-4 5,6-Dimethoxy-2-[(4-piperidyl) methyl]indan-1-one > 99.0
    120014-30-4
    View Details
  • 147403-65-4 > 99
    147403-65-4 > 99
    147403-65-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.