OSI-027
- CAS NO.:936890-98-1
- Empirical Formula: C21H22N6O3
- Molecular Weight: 406.44
- MDL number: MFCD20275101
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is OSI-027?
Description
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of mTOR and, as a result, inhibits both mTORC1 and mTORC2 (IC50s = 22 and 65 nM, respectively). It is selective for mTOR over phosphatidylinositol 3-kinase isoforms and DNA protein kinase. OSI-027 prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 μM. OSI-027 is effective in vivo, blocking the phosphorylation of targets of mTORC1 and mTORC2 and suppressing tumor growth in several different human xenograft models.
The Uses of OSI-027
OSI-027 is a kinase inhibitor with anti-tumor activity, used in treatment of breast cancer.
What are the applications of Application
OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor
Definition
ChEBI: 4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-cyclohexanecarboxylic acid is a member of indoles.
References
[1] bhagwat s v, gokhale p c, crew a p, et al. preclinical characterization of osi-027, a potent and selective inhibitor of mtorc1 and mtorc2: distinct from rapamycin. molecular cancer therapeutics, 2011, 10(8): 1394-1406.
Properties of OSI-027
Melting point: | >149°C (subl.) |
Density | 1.59 |
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | DMSO (Slightly) |
form | Solid |
pka | 4.44±0.10(Predicted) |
color | Pale Beige to Light Beige |
Safety information for OSI-027
Computed Descriptors for OSI-027
New Products
Tubulysin B Tubulysin D Tubulysin I Tubulysin A 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one 4-FLUOROPIPERIDINE Cyclobutanamine, 3,3-difluoro- (9CI) 5-Methyl-1-indanone CYCLOBUTYLAMINE HYDROCHLORIDE 3-N-BOC-(S)-AMINO BUTYRONITRILE 4-(2-fluoro-4- nitrophenyl) thiomorpholine 3-(S)-(+)- (1-Cyano-1,1- diphenylmethyl)- 1-tosylpyrrolidine (S)-4-(azidomethyl) -3-(3-fluoro-4- thiomorpholino phenyl) oxazolidin-2-one 1-(2,3-Dihydro- benzofuran-5-yl) -ethanone 7-chloro-1- (2-methyl-4- nitrobenzoyl)-3,4- dihydro-1H-benzo[b] azepin-5(2H)-one (2,3-Dihydro- benzofuran-5-yl)- ethanol 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile (R)-methyl 2-formamido-3-(tritylthio)propanoate (R)-methyl 2-isocyano-3-(tritylthio)propanoate Quetiapine EP Impurity B | Quetiapine USP Related Compound B EZETIMIBE (RSS) ISOMER Lamivudine EP Impurity H / Lamivudine (3R)-SulfoxideRelated products of tetrahydrofuran
You may like
-
OSI-027 >95% CAS 936890-98-1View Details
936890-98-1 -
3-(4-Chloro-butyryl) -1H-indole-5- carbonitrileView Details
276863-95-7 -
Ethyl 5-Aminobenzofuran-2- CarboxylateView Details
174775-48-5 -
BenzofuranView Details
271-89-6 -
(2,3-Dihydro- benzofuran-5-yl)- ethanolView Details
87776-76-9 -
3-(S)-(+)- (1-Cyano-1,1- diphenylmethyl)- 1-tosylpyrrolidineView Details
133099-09-9 -
2,3-dichloro-6- nitrobenzonitrileView Details
2112-23-2 -
2,3-Dichloro-6- nitrobenzylamine HydrochlorideView Details
70380-49-3