Cediranib
- CAS NO.:288383-20-0
- Empirical Formula: C25H27FN4O3
- Molecular Weight: 450.51
- MDL number: MFCD09954115
- EINECS: 670-946-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-02 10:08:32
What is Cediranib?
Description
Receptors for VEGF have central roles in vasculogenesis and angiogenesis and thus serve as targets for cancer therapy. Cediranib is a potent inhibitor of VEGF receptor tyrosine kinases, including VEGFR1, 2, and 3 (IC50s = 5, 1, and 3 nM, respectively). It also potently inhibits a variety of other receptor and non-
The Uses of Cediranib
Cediranib (AZD2171) inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM, respectively.
The Uses of Cediranib
Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug and clinical application progress, value of correlative biomakers in the understanding of tumor biology.
Definition
ChEBI: 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline is an aromatic ether.
storage
Store at -20°C
References
[1] wedge sr, kendrew j, hennequin lf, valentine pj, barry st, brave sr, smith nr, james nh, dukes m, curwen jo, chester r, jackson ja, boffey sj, kilburn ll, barnett s, richmond gh, wadsworth pf, walker m, bigley al, taylor st, cooper l, beck s, jürgensmeier jm, ogilvie dj. azd2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. cancer res. 2005 may 15;65(10):4389-400.
Properties of Cediranib
Melting point: | 135-138°C |
Boiling point: | 626.6±55.0 °C(Predicted) |
Density | 1.285 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 16.14±0.30(Predicted) |
color | White to Off-White |
Safety information for Cediranib
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cediranib
New Products
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