TYRPHOSTIN AG 1296
Synonym(s):6,7-Dimethoxy-3-phenylquinoxaline;AG 1296 - CAS 146535-11-7 - Calbiochem
- CAS NO.:146535-11-7
- Empirical Formula: C16H14N2O2
- Molecular Weight: 266.29
- MDL number: MFCD00270913
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:01:57
What is TYRPHOSTIN AG 1296?
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-
The Uses of TYRPHOSTIN AG 1296
Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.
What are the applications of Application
AG-1296 is a potent inhibitor of PDGFR kinase and c-Kit
Definition
ChEBI: 6,7-dimethoxy-2-phenylquinoxaline is a quinoxaline derivative.
References
1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260 2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 220 3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579
Properties of TYRPHOSTIN AG 1296
Boiling point: | 420.2±40.0 °C(Predicted) |
Density | 1.192±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
solubility | Soluble in DMSO. |
pka | 0.48±0.30(Predicted) |
form | White solid |
color | Yellow |
Sensitive | Light Sensitive |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for TYRPHOSTIN AG 1296
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TYRPHOSTIN AG 1296
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