AZD-4547
- CAS NO.:1035270-39-3
- Empirical Formula: C26H33N5O3
- Molecular Weight: 463.57
- MDL number: MFCD22580423
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is AZD-4547?
Description
AZD 4547 is a selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase with IC50 values of 0.2, 2.5, and 1.8 nM for FGFR1, 2, and 3, respectively. It displays weaker activity against FGFR4 (IC50 = 165 nM), VEGFR2 (IC50 = 24 nM), and a panel of other tyrosine and serine/theronine kinases such as insulin-
Chemical properties
Pale Yellow Solid
The Uses of AZD-4547
AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine k inases and is under clinical investigation for the treatment of FGFR-dependent tumors.
Definition
ChEBI: AZD4547 is a member of the class of benzamides that is a carboxamide resulting from the formal condensation of the carboxy group of 4-(cis-3,5-dimethylpiperazin-1-yl)benzoic acid with the amino substituent of 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-amine. It is an inhibitor of the fibroblast growth factor receptor (FGFR). It has a role as a fibroblast growth factor receptor antagonist. It is a member of pyrazoles, a N-arylpiperazine and a member of benzamides.
What are the applications of Application
AZD4547 is a novel selective FGFR inhibitor targeting Flg (FGFR1), Bek (FGFR2), and FGFR-3
storage
Store at -20°C
Properties of AZD-4547
Melting point: | 168-170°C |
Boiling point: | 621.7±55.0 °C(Predicted) |
Density | 1.189 |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.66±0.10(Predicted) |
color | Pale Yellow to Light Beige |
Safety information for AZD-4547
Computed Descriptors for AZD-4547
New Products
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