TYRPHOSTIN AG 1024
Synonym(s):3-Bromo-5- t-butyl-4-hydroxy-benzylidenemalonitrile;AG 1024 - CAS 65678-07-1 - Calbiochem
- CAS NO.:65678-07-1
- Empirical Formula: C14H13BrN2O
- Molecular Weight: 305.17
- MDL number: MFCD02179365
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 15:28:16
What is TYRPHOSTIN AG 1024?
Description
The binding of insulin-
The Uses of TYRPHOSTIN AG 1024
Tyrphostin AG 1024 is an insulin-like growth factor (IGF)-I receptor antagonist.
What are the applications of Application
AG 1024 is inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation
Definition
ChEBI: 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile is an alkylbenzene.
References
[1] párrizas m1, gazit a, levitzki a, wertheimer e, leroith d. specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. endocrinology. 1997 apr;138(4):1427-33.
[2] fan p1, agboke fa1, mcdaniel re1, sweeney ee1, zou x1, creswell k1, jordan vc2.inhibition of c-src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. eur j cancer. 2014 jan; 50(2):457-68.
Properties of TYRPHOSTIN AG 1024
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO: soluble |
form | solid |
color | yellow |
Safety information for TYRPHOSTIN AG 1024
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TYRPHOSTIN AG 1024
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