Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listtrofosfamide

trofosfamide

trofosfamide  Structural

What is trofosfamide ?

Chemical properties

Off-White Low Melting Solid

Originator

Ixoten,Asta,W. Germany,1973

The Uses of trofosfamide

Antineoplastic; one derivative

What are the applications of Application

Trofosfamide is an anti-neoplastic derivative of cyclophosphamide

Definition

ChEBI: Trofosfamide is a member of ifosfamides.

Manufacturing Process

259 g (1 mol) of N,N-bis-(2-chloroethyl)-phosphoric acid amide dichloride, 209 g (1.2 mols) of N-(2-chloroethyl)-N-(3-hydroxypropyl)-amine hydrochloride (crude), 1,000 cc of ethylene dichloride and 344 g (3.4 mols) of triethylamine are the reactants. N,N-bis-(2-chloroethyl)-phosphoric acid amide dichloride is dissolved in the methylene dichloride. N-(2-chloroethyl)-N-(3- hydroxypropyl)-amine hydrochloride is suspended in this solution and triethylamine is added thereto dropwise with stirring. The temperature of the solution rises to boiling, After the termination of the addition, the mixture is heated to boiling for another 6 hours. Thereafter, the reaction mixture is cooled down and allowed to stand overnight at about 0°C. The precipitated triethylamine hydrochloride is filtered off with suction. The resulting solution is evaporated, the residue (about 370 g) is triturated with about 3.2 liters of ether and is heated to boiling for a short period of time.
The ethereal solution is decanted from the insolubles (about 90 g). The solution is rendered to pH 6.5 to 7 by the addition of ethereal hydrochloric acid and then is filtered over charcoal and thereafter is evaporated. During evaporation, the temperature should not rise above 40°C. The residue is dissolved in ether and in an amount corresponding to half of its weight (240 g of residue, dissolved in 120 cc of ether), the ethereal solution is cooled to - 5°C and is inoculated. After standing for 25 hours, 140 g have been separated by crystallization. After separation by filtration with suction, the mother liquor is diluted with ether to 5 times its volume, the solution is filtered over charcoal, is again evaporated and the residue is again dissolved in a volume corresponding to half of the weight of the residue. Another cooling to -5°C and inoculation produces further 18 g of the desired compound. MP: 50° to 51°C. Total yield: 161 g (50% of the theoretical)

Therapeutic Function

Cancer chemotherapy

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. Human systemic effects by unspecified routes: hematuria, leukopenia, and thrombocytopenia. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and POx.

Properties of trofosfamide

Melting point: 47-49°C
Boiling point: 104°C
alpha  D25 -28.6° (c = 2 in CH3OH)
Density  1.35±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMF: 50mg/mL; DMSO: 30mg/mL; Ethanol: 50mg/mL; PBS (pH 7.2): 10mg/mL
form  A crystalline solid
pka -0.46±0.20(Predicted)

Safety information for trofosfamide

Computed Descriptors for trofosfamide

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.