phosphoramide mustard
- CAS NO.：10159-53-2
- Empirical Formula: C4H11Cl2N2O2P
- Molecular Weight: 221.02
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:30
What is phosphoramide mustard?
Definition
ChEBI: Phosphoramide mustard is a nitrogen mustard and a phosphorodiamide.
Biological Activity
Phosphoramide mustard is the active metabolite of cyclophosphamide (HY-17420) with antitumor activity. It induces DNA damage.
in vitro
Phosphoramide mustard causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.
It (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells ( SIGCs).
Phosphoramide mustard (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.
It (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.
Cell Viability Assay
| Cell Line: | SIGCs |
| Concentration: | 0.5 μM, 1 μM, 3 μM, 6 μM |
| Incubation Time: | 48 hours |
| Result: | Reduced ce ll viability at concentrations of 3 μM and higher. |
RT-PCR
| Cell Line: | SIGCs |
| Concentration: | 3 μM, 6 μM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Increased DDR gene mRNA expression levels. |
Western Blot Analysis
| Cell Line: | SIGCs | < /tr>
| Concentration: | 3 μM, 6 μM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Generally increased DDR pro teins. |
Properties of phosphoramide mustard
| Melting point: | 115 °C |
| Boiling point: | 363.5±52.0 °C(Predicted) |
| Density | 1.474±0.06 g/cm3(Predicted) |
| pka | 0.41±0.50(Predicted) |
Safety information for phosphoramide mustard
Computed Descriptors for phosphoramide mustard
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