Trifluoroacetamidine
- CAS NO.：354-37-0
- Empirical Formula: C2H3F3N2
- Molecular Weight: 112.05
- MDL number: MFCD00041545
- EINECS: 670-531-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-06 17:20:39
What is Trifluoroacetamidine?
Chemical properties
Colorless liquid
The Uses of Trifluoroacetamidine
Trifluoroacetamidine is used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies. It is a reagent used as protected ammonia equivalent.
Synthesis
Trifluoroacetamidine is a vital chemical intermediate with a wide range of applications. A preparation method comprises the following steps: trifluoroacetamide is used as raw materials, polyphosphoric acid is selected as solvents under the effect of phosphorus pentoxide as dehydrating agents, and trifluoroacetonitrile can be fast prepared through a dehydration reaction. The generated trifluoroacetonitrile gas is introduced into a liquid ammonia kettle after being cooled, and the trifluoroacetamidine can be prepared.
Properties of Trifluoroacetamidine
| Boiling point: | 35-37°C 11mm |
| Density | 1.45 |
| refractive index | 1.3801 |
| Flash point: | 35-37°C/11mm |
| storage temp. | Store below -20C |
| pka | 6.07±0.40(Predicted) |
| color | Clear, yellow |
| Water Solubility | Fully miscible in water. |
| Sensitive | Moisture Sensitive |
| BRN | 605978 |
| InChI | InChI=1S/C2H3F3N2/c3-2(4,5)1(6)7/h(H3,6,7) |
| CAS DataBase Reference | 354-37-0(CAS DataBase Reference) |
Safety information for Trifluoroacetamidine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Trifluoroacetamidine
| InChIKey | NITMACBPVVUGOJ-UHFFFAOYSA-N |
| SMILES | C(N)(=N)C(F)(F)F |
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