Trifluoroacetamidine

CAS NO.：354-37-0
Empirical Formula: C2H3F3N2
Molecular Weight: 112.05
MDL number: MFCD00041545
EINECS: 670-531-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-06 17:20:39

What is Trifluoroacetamidine?

Chemical properties

Colorless liquid

The Uses of Trifluoroacetamidine

Trifluoroacetamidine is used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies. It is a reagent used as protected ammonia equivalent.

Synthesis

Trifluoroacetamidine is a vital chemical intermediate with a wide range of applications. A preparation method comprises the following steps: trifluoroacetamide is used as raw materials, polyphosphoric acid is selected as solvents under the effect of phosphorus pentoxide as dehydrating agents, and trifluoroacetonitrile can be fast prepared through a dehydration reaction. The generated trifluoroacetonitrile gas is introduced into a liquid ammonia kettle after being cooled, and the trifluoroacetamidine can be prepared.

Properties of Trifluoroacetamidine

Boiling point:	35-37°C 11mm
Density	1.45
refractive index	1.3801
Flash point:	35-37°C/11mm
storage temp.	Store below -20C
pka	6.07±0.40(Predicted)
color	Clear, yellow
Water Solubility	Fully miscible in water.
Sensitive	Moisture Sensitive
BRN	605978
InChI	InChI=1S/C2H3F3N2/c3-2(4,5)1(6)7/h(H3,6,7)
CAS DataBase Reference	354-37-0(CAS DataBase Reference)

Safety information for Trifluoroacetamidine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.