Chlorotrimethylsilane
Synonym(s):TMSCl;Chlorotrimethylsilane;Trimethylsilyl chloride;TMCS;Trimethylchlorosilane
- CAS NO.:75-77-4
- Empirical Formula: C3H9ClSi
- Molecular Weight: 108.64
- MDL number: MFCD00000502
- EINECS: 200-900-5
- Update Date: 2023-08-30 19:07:15
What is Chlorotrimethylsilane?
Description
Chlorotrimethylsilane is a valuable reagent for the protection of the hydroxyl function in organic synthesis. It should be distilled from calciumhydride (or tributylamine) under nitrogen before use,and stored and weighed under nitrogen. Use of the reagent without purification has been reported to lead to explosions. Chlorotrimethylsilane may contain dichlorodimethylsilane as an impurity. This may be removed before distillation by very cautious treatment with a small amount of water,which hydrolyses the dichloro compound more rapidly. Excess chlorotrimethylsilane in a reaction mixture may be destroyed by the very careful addition of aqueous sodium hydrogencarbonate solution.
The Uses of Chlorotrimethylsilane
Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.
Properties of Chlorotrimethylsilane
Melting point: | −40 °C(lit.) |
Boiling point: | 57 °C(lit.) |
Density | 0.857 g/mL at 25 °C |
Flash point: | 104 °F |
storage temp. | Store below +30°C. |
solubility | Miscible with ether, benzene, diethylether and perchloroethylene. |
form | Liquid |
color | Clear colorless |
Water Solubility | REACTS |
Sensitive | Moisture Sensitive |
Safety information for Chlorotrimethylsilane
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H225:Flammable liquids H312:Acute toxicity,dermal H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Chlorotrimethylsilane
InChIKey | IJOOHPMOJXWVHK-UHFFFAOYSA-N |
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