trans-Chalcone
Synonym(s):Benzalacetophenone;Benzylideneacetophenone;Chalcone
- CAS NO.:614-47-1
- Empirical Formula: C15H12O
- Molecular Weight: 208.26
- MDL number: MFCD00003082
- EINECS: 210-383-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is trans-Chalcone?
Description
trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.
Chemical properties
Trans-Chalcone is a yellowish crystals. M.P. 58℃. (trans-isomer). M .P. 46℃. (cis-isomer).Sp.Gr. 1.07 (liquid).Insoluble in water, soluble in alcohol (poorly) and oils.
The Uses of trans-Chalcone
trans-Chalcone is a positive allosteric modulator of α7 nicotinic acetylcholine receptors and exhibits antioxidant activity.
What are the applications of Application
Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer
What are the applications of Application
trans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H6P2W18O62.xH2O).
Preparation
trans-Chalcones have been obtained in good yields and selectivities following an environmentally friendly methodology by using montmorillonite KSF as a reusable heterogeneous catalyst.
Clay-catalysed solventless synthesis of trans-chalcones
Definition
ChEBI: Chalcone is a member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. It has a role as a plant metabolite. It is a member of styrenes and a member of chalcones.
Synthesis Reference(s)
Journal of the American Chemical Society, 104, p. 4724, 1982 DOI: 10.1021/ja00381a058
General Description
trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.
Biological Activity
trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.
Biochem/physiol Actions
trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.
Synthesis
Trans-Chalcone is synthesized by condensation of Benzaldehyde with Acetophenone.
Properties of trans-Chalcone
Melting point: | 55-59 °C |
Boiling point: | 208 °C25 mm Hg(lit.) |
Density | 1.0712 |
refractive index | 1.5361 (estimate) |
Flash point: | >230 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly) |
form | Solid |
color | Pale Yellow |
Odor | at 100.00 %. floral balsam herbal |
Water Solubility | Soluble in chloroform, ether, benzene, and ethanol (slightly). Insoluble in water. |
Merck | 14,2037 |
BRN | 509985 |
CAS DataBase Reference | 614-47-1(CAS DataBase Reference) |
NIST Chemistry Reference | Benzalacetophenone(614-47-1) |
Safety information for trans-Chalcone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for trans-Chalcone
Abamectin manufacturer
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