trans-Chalcone

Synonym(s):Benzalacetophenone;Benzylideneacetophenone;Chalcone

CAS NO.：614-47-1
Empirical Formula: C15H12O
Molecular Weight: 208.26
MDL number: MFCD00003082
EINECS: 210-383-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

What is trans-Chalcone?

Description

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Chemical properties

Trans-Chalcone is a yellowish crystals. M.P. 58℃. (trans-isomer). M .P. 46℃. (cis-isomer).Sp.Gr. 1.07 (liquid).Insoluble in water, soluble in alcohol (poorly) and oils.

The Uses of trans-Chalcone

trans-Chalcone is a positive allosteric modulator of α7 nicotinic acetylcholine receptors and exhibits antioxidant activity.

What are the applications of Application

Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer

What are the applications of Application

trans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H6P2W18O62.xH2O).

Preparation

trans-Chalcones have been obtained in good yields and selectivities following an environmentally friendly methodology by using montmorillonite KSF as a reusable heterogeneous catalyst.
Clay-catalysed solventless synthesis of trans-chalcones

Definition

ChEBI: Chalcone is a member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. It has a role as a plant metabolite. It is a member of styrenes and a member of chalcones.

Synthesis Reference(s)

Journal of the American Chemical Society, 104, p. 4724, 1982 DOI: 10.1021/ja00381a058

General Description

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Biological Activity

trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

Biochem/physiol Actions

Synthesis

Trans-Chalcone is synthesized by condensation of Benzaldehyde with Acetophenone.

Properties of trans-Chalcone

Melting point:	55-59 °C
Boiling point:	208 °C25 mm Hg(lit.)
Density	1.0712
refractive index	1.5361 (estimate)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly)
form	Solid
color	Pale Yellow
Odor	at 100.00 %. floral balsam herbal
Water Solubility	Soluble in chloroform, ether, benzene, and ethanol (slightly). Insoluble in water.
Merck	14,2037
BRN	509985
CAS DataBase Reference	614-47-1(CAS DataBase Reference)
NIST Chemistry Reference	Benzalacetophenone(614-47-1)

Safety information for trans-Chalcone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.