DIPHENYLCYCLOPROPENONE
Synonym(s):2,3-Diphenyl-2-cyclopropen-1-one;DPC
- CAS NO.：886-38-4
- Empirical Formula: C15H10O
- Molecular Weight: 206.24
- MDL number: MFCD00001311
- EINECS: 212-948-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-25 18:01:02
What is DIPHENYLCYCLOPROPENONE?
Description
Diphencyprone is a potent contact allergen responsible for occupational contact dermatitis in chemists and dermatological staff.
Description
Diphencyprone (DCP) is a contact sensitizing agent. Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP1-10). It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v. Topical administration of DCP increases intrafollicular CD4+ and CD8+ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta. Formulations containing DCP have been used in the treatment of alopecia areta.
Chemical properties
slightly pinkish-orange to beige crystalline
The Uses of DIPHENYLCYCLOPROPENONE
Diphenylcyclopropenone was used in topical immunotherapy.
Definition
ChEBI: A cyclopropenone compound having phenyl substituents at the 2- and 3-positions.
General Description
Diphenylcyclopropenone is a potent hapten. Its vibration frequency has been evaluated.
Contact allergens
Diphencyprone is a potent contact allergen used in topical immunotherapy to treat some severe alopecia areata. It is responsible for occupational contact dermatitis in chemists and dermatology department staff
Purification Methods
Crystallise it from cyclohexane. UV (MeCN): max 226, 282, 297nm. [Beilstein 17 IV 1736.]
Properties of DIPHENYLCYCLOPROPENONE
| Melting point: | 118-122 °C (lit.) |
| Boiling point: | 305.09°C (rough estimate) |
| Density | 1.232 |
| refractive index | 1.6324 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMF:20.0(Max Conc. mg/mL);96.97(Max Conc. mM) DMSO:20.0(Max Conc. mg/mL);96.97(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);2.42(Max Conc. mM) Ethanol:14.0(Max Conc. mg/mL);67.88(Max Conc. mM) |
| form | Crystalline Powder |
| color | Slightly pinkish-orange to beige |
| Merck | 14,3308 |
| BRN | 608049 |
| CAS DataBase Reference | 886-38-4(CAS DataBase Reference) |
Safety information for DIPHENYLCYCLOPROPENONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
Computed Descriptors for DIPHENYLCYCLOPROPENONE
| InChIKey | HCIBTBXNLVOFER-UHFFFAOYSA-N |
Abamectin manufacturer
Sris Synthesis Pvt Ltd.,
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