Tolperisone
- CAS NO.:728-88-1
- Empirical Formula: C16H23NO
- Molecular Weight: 245.36
- MDL number: MFCD00242995
- EINECS: 211-976-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:41
What is Tolperisone?
Originator
Tolperisone hydrochloride,Shanghai Abochem Chemical Co.
Definition
ChEBI: 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone is an aromatic ketone.
Manufacturing Process
To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.
brand name
Tolperisone Hydrochloride is JAN.
Therapeutic Function
Muscle relaxant, Vasodilator
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 42, p. 1676, 1994 DOI: 10.1248/cpb.42.1676
Properties of Tolperisone
Melting point: | 176.5°C |
Boiling point: | 388.33°C (rough estimate) |
Density | 0.9672 (rough estimate) |
refractive index | 1.5500 (estimate) |
pka | 8.47±0.10(Predicted) |
CAS DataBase Reference | 728-88-1(CAS DataBase Reference) |
Safety information for Tolperisone
Computed Descriptors for Tolperisone
Abamectin manufacturer
Sai Tech Pharamceuticals Pvt Ltd
New Products
Tubulysin M Tubulysin B Tubulysin A Tubulysin H 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 1-(1,1-Difluoroethyl)-2-fluorobenzene 3-N-BOC-(S)-AMINO BUTYRONITRILE 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
Tolperisone 98%View Details
-
728-88-1 98%View Details
728-88-1 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8