Tolperisone hydrochloride
Synonym(s):2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one hydrochloride;Menopatol
- CAS NO.:3644-61-9
- Empirical Formula: C16H24ClNO
- Molecular Weight: 281.82
- MDL number: MFCD00058211
- EINECS: 222-876-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-16 15:32:52
What is Tolperisone hydrochloride?
Chemical properties
White Solid
Originator
Tolperisone hydrochloride,Shanghai Abochem Chemical Co.
The Uses of Tolperisone hydrochloride
Tolperisone hydrochloride can be used as a muscle relaxant.
What are the applications of Application
Tolperisone Hydrochloride is An ion channel blocker
Definition
ChEBI: Tolperisone hydrochloride is an aromatic ketone.
Manufacturing Process
To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.
Therapeutic Function
Muscle relaxant, Vasodilator
Biochem/physiol Actions
Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.
Properties of Tolperisone hydrochloride
Melting point: | 181-183°C |
storage temp. | room temp |
solubility | H2O: >20mg/mL |
form | solid |
color | white |
PH | pH(50g/l, 25℃) : 4.5~5.5 |
Water Solubility | almost transparency |
Merck | 14,9522 |
CAS DataBase Reference | 3644-61-9(CAS DataBase Reference) |
Safety information for Tolperisone hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for Tolperisone hydrochloride
Abamectin manufacturer
Afton Pharma
Global Calcium Pvt Ltd
Ralington Pharma
VAIKUNTH CHEMICAL PVT. LTD.
Pharma Links
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