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HomeProduct name listTolperisone hydrochloride

Tolperisone hydrochloride

Synonym(s):2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one hydrochloride;Menopatol

  • CAS NO.:3644-61-9
  • Empirical Formula: C16H24ClNO
  • Molecular Weight: 281.82
  • MDL number: MFCD00058211
  • EINECS: 222-876-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-16 15:32:52
Tolperisone hydrochloride Structural

What is Tolperisone hydrochloride?

Chemical properties

White Solid

Originator

Tolperisone hydrochloride,Shanghai Abochem Chemical Co.

The Uses of Tolperisone hydrochloride

Tolperisone hydrochloride can be used as a muscle relaxant.

What are the applications of Application

Tolperisone Hydrochloride is An ion channel blocker

Definition

ChEBI: Tolperisone hydrochloride is an aromatic ketone.

Manufacturing Process

To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.

Therapeutic Function

Muscle relaxant, Vasodilator

Biochem/physiol Actions

Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.

Properties of Tolperisone hydrochloride

Melting point: 181-183°C
storage temp.  room temp
solubility  H2O: >20mg/mL
form  solid
color  white
PH pH(50g/l, 25℃) : 4.5~5.5
Water Solubility  almost transparency
Merck  14,9522
CAS DataBase Reference 3644-61-9(CAS DataBase Reference)

Safety information for Tolperisone hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for Tolperisone hydrochloride

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