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HomeProduct name listThioproperazine

Thioproperazine

  • CAS NO.:316-81-4
  • Empirical Formula: C22H30N4O2S2
  • Molecular Weight: 446.63
  • MDL number: MFCD00867741
  • EINECS: 2062624
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
Thioproperazine Structural

What is Thioproperazine?

Originator

Majeptil,Specia,France,1960

Definition

ChEBI: A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.

Manufacturing Process

A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100 cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1- piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is added and the mixture heated under reflux for 5 hours. After treatment of the reaction products, a crude oily base (2.5 g) is obtained after treatment. By the addition of a solution of fumaric acid in ethanol to an ethanolic solution of the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)- phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The base recrystallized from ethyl acetate melts at about 140°C.

Therapeutic Function

Neuroleptic, Antiemetic

Properties of Thioproperazine

Melting point: 140°
Boiling point: 612.2±65.0 °C(Predicted)
Density  1.1476 (rough estimate)
refractive index  1.6200 (estimate)
storage temp.  Sealed in dry,Room Temperature
pka 7.65±0.10(Predicted)
form  Solid
color  Light yellow to yellow
NIST Chemistry Reference Thioproperazine(316-81-4)

Safety information for Thioproperazine

Computed Descriptors for Thioproperazine

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