Tetrahydropyran
Synonym(s):Pentamethylene oxide
- CAS NO.:142-68-7
- Empirical Formula: C5H10O
- Molecular Weight: 86.13
- MDL number: MFCD00006585
- EINECS: 205-552-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-16 08:48:31
What is Tetrahydropyran?
Description
Tetrahydropyran (THP) is the organic compound consisting of a saturated six-membered ring containing five carbon atoms and one oxygen atom. It is named by reference to pyran, which contains two double bonds, and may be produced from it by adding four hydrogens. Tetrahydropyran can be used as a solvent in various classical organic reactions such as radical reactions, palladium-catalyzed coupling, and Grignard reactions.
Chemical properties
colorless to light yellow liquid
The Uses of Tetrahydropyran
It is is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. They are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization.
Definition
ChEBI: A saturated organic heteromonocyclic parent that is cyclohexane in which one of the carbon atoms has been replaced by an oxygen atom.
Purification Methods
Dry oxane with CaH2, then pass it through a column of silica gel to remove olefinic impurities and fractionally distil it. Free it from peroxides and moisture by refluxing with sodium, then distil it from LiAlH4. Alternatively, peroxides can be removed by treatment with aqueous ferrous sulfate and sodium bisulfate, followed by solid KOH, and fractional distillation from sodium. [Beilstein 17 H 12, 17 I 6, 17 II 18, 17 III/IV 51, 17/1 V 64.]
Properties of Tetrahydropyran
Melting point: | -45 °C (lit.) |
Boiling point: | 88 °C (lit.) |
Density | 0.881 g/mL at 25 °C (lit.) |
vapor density | 3 (vs air) |
refractive index | n |
Flash point: | 4 °F |
storage temp. | Store below +30°C. |
solubility | >80.2g/l |
form | Liquid |
color | Clear colorless |
Odor | at 0.10?%?in?dipropylene glycol. pungent sweet ethereal |
Water Solubility | 80 g/L (25 ºC) |
Merck | 14,9217 |
BRN | 102436 |
Dielectric constant | 7.3(30℃) |
CAS DataBase Reference | 142-68-7(CAS DataBase Reference) |
NIST Chemistry Reference | 2H-Pyran, tetrahydro-(142-68-7) |
EPA Substance Registry System | Tetrahydropyran (142-68-7) |
Safety information for Tetrahydropyran
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 |
GHS Hazard Statements |
H225:Flammable liquids |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. |
Computed Descriptors for Tetrahydropyran
InChIKey | DHXVGJBLRPWPCS-UHFFFAOYSA-N |
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JSK Chemicals
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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