HECOGENIN ACETATE
Synonym(s):(−)-Hecogenin acetate
- CAS NO.:915-35-5
- Empirical Formula: C29H44O5
- Molecular Weight: 472.66
- MDL number: MFCD00005088
- EINECS: 213-021-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-26 21:18:56
What is HECOGENIN ACETATE?
Description
Hecogenin acetate is a steroid sapogenin and an acetylated form of hecogenin that has anthelmintic and antinociceptive properties. It reduces the percentage of mobile larvae in goat fecal cultures containing Haemonchus, Oesophagostomum, and Trichostrongylus nematodes (EC50 = 0.49 mg/ml). Hecogenin acetate (5, 10, or 20 mg/kg, i.p.) inhibits development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine , and prostaglandin E2 (PGE2; ) in mice. It also increases latency to tail withdrawal in the tail flick test and has no effect on motor performance in the rotarod test in mice when administered at a dose of 40 mg/kg.
The Uses of HECOGENIN ACETATE
Hecogenin Acetate, is a derivative of Hecogenin (H129945), which is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.
Definition
ChEBI: HECOGENIN ACETATE is a triterpenoid.
Purification Methods
Crystallise the acetate from MeOH. [Beilstein 19 IV 2583.]
Properties of HECOGENIN ACETATE
Melting point: | 246-248 °C (dec.)(lit.) |
Boiling point: | 95-140 °C |
Density | 1.15±0.1 g/cm3(Predicted) |
refractive index | -4 ° (C=1, Dioxane) |
storage temp. | Refrigerator |
solubility | Chloroform (Sparingly), Dioxane (Sparingly, Heated), Ethyl Acetate (Slightly, He |
form | Solid |
color | White |
Safety information for HECOGENIN ACETATE
Computed Descriptors for HECOGENIN ACETATE
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