TETRACHLOROHYDROQUINONE
- CAS NO.：87-87-6
- Empirical Formula: C6H2Cl4O2
- Molecular Weight: 247.89
- MDL number: MFCD00041748
- EINECS: 201-779-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is TETRACHLOROHYDROQUINONE?
Description
Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.
Chemical properties
LIGHT BEIGE CRYSTALLINE POWDER
The Uses of TETRACHLOROHYDROQUINONE
Tetrachlorohydroquinone is a chlorinated hydroquinone compound used as an analytical standard.
What are the applications of Application
Tetrachlorohydroquinone is a tchlorinated hydroquinone compound used as an analytical standard
Definition
ChEBI: A tetrachlorobenzene that is 1,2,4,5-tetrachlorobenzene in which the hydrogens at positions 3 and 6 are replaced by hydroxy groups.
Purification Methods
Crystallise the quinone from EtOH or AcOH/EtOH. Sublime it at 77o/0.6x10-3mm. The dibenzoyl derivative has m 233o. [Conant & Fieser J Am Chem Soc 45 2207 1923, Rabideau et al. J Am Chem Soc 108 8130 1986, Beilstein 6 H 851, 6 I 417, 6 II 846, 6 III 4436, 6 IV 5775.]
Properties of TETRACHLOROHYDROQUINONE
| Melting point: | 238-240 °C |
| Boiling point: | 352.31°C (rough estimate) |
| Density | 1.8232 (rough estimate) |
| refractive index | 1.4813 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Sparingly), Methanol (Slightly, Heated) |
| pka | 5.54±0.33(Predicted) |
| form | Solid |
| color | Off-White to Light Orange |
| Water Solubility | 21.5mg/L(temperature not stated) |
| CAS DataBase Reference | 87-87-6(CAS DataBase Reference) |
| EPA Substance Registry System | 2,3,5,6-Tetrachlorohydroquinone (87-87-6) |
Safety information for TETRACHLOROHYDROQUINONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to..… |
Computed Descriptors for TETRACHLOROHYDROQUINONE
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