Chlorohydroquinone

Synonym(s):2-Chloro-1,4-dihydroxybenzene

CAS NO.：615-67-8
Empirical Formula: C6H5ClO2
Molecular Weight: 144.56
MDL number: MFCD00002341
EINECS: 210-442-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-14 18:30:21

What is Chlorohydroquinone?

Chemical properties

light brown to grey fine crystalline powder. It precipitates leafy crystals from chloroform and needle-like crystals from toluene. Freely soluble in water and alcohol, slightly soluble in ether and hot chloroform.

The Uses of Chlorohydroquinone

Chlorohydroquinone is a component of polyethers based on organotin with potential application to breast cancer treatment via growth inhibition. Also a component in the synthesis of contraceptive agents in pharmaceutical compounds. It is also used within hydroxylation and catalysis organic reactions in the synthesis of pharmacologically active phenolic compounds.

What are the applications of Application

Chlorohydroquinone is a chlorinated hydroxyphenol

Definition

ChEBI: Chlorohydroquinone is a benzenediol that consists of hydroquinone bearing a single chloro substituent. It has a role as a metabolite. It is a member of monochlorobenzenes and a member of chlorohydroquinones.

Preparation

Chlorohydroquinone is obtained by reacting p-benzoquinone with hydrochloric acid. First dissolve p-benzoquinone with chloroform and pass dry hydrogen chloride gas under cooling to obtain.

What are the applications of Application

Chlorohydroquinone is a benzenediol that consists of hydroquinone bearing a single chloro substituent. It has a role as a metabolite. It is a member of monochlorobenzenes and a member of chlorohydroquinones. Chlorohydroquinone is used in photographic developing solutions. It is also a bactericide.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by skin contact. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES.

Purification Methods

Crystallise the hydroquinone from CHCl3 or toluene. [Beilstein 6 IV 5767.]

Properties of Chlorohydroquinone

Melting point:	100-104 °C (lit.)
Boiling point:	263 °C (lit.)
Density	1.2558 (rough estimate)
refractive index	1.4620 (estimate)
Flash point:	263°C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Fine Crystalline Powder
pka	9.21±0.18(Predicted)
color	Light brown to gray
Water Solubility	soluble
BRN	636835
CAS DataBase Reference	615-67-8(CAS DataBase Reference)
NIST Chemistry Reference	1,4-Benzenediol, 2-chloro-(615-67-8)
EPA Substance Registry System	Chlorohydroquinone (615-67-8)

Safety information for Chlorohydroquinone

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.