2,3,5,6-TETRACHLOROPHENOL
- CAS NO.:935-95-5
- Empirical Formula: C6H2Cl4O
- Molecular Weight: 231.89
- MDL number: MFCD00044671
- EINECS: 213-310-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:03
What is 2,3,5,6-TETRACHLOROPHENOL?
Chemical properties
Brown solid; phenol odor. Soluble in sodium hydroxide solutions and most organic solvents; insoluble in water.
The Uses of 2,3,5,6-TETRACHLOROPHENOL
Fungicide, wood preservative.
Definition
ChEBI: The 2,3,5,6-isomer of tetrachlorophenol
Production Methods
Chlorophenols are generally prepared by the chlorination of phenol. There are other routes of synthesis as through diazotizing p-chloroaniline or dechlorinating (by alkaline hydrolysis) 1,2,4,5-tetrachlorobenzene to yield 2,4,5-trichlorophenol (TCP). Polychlorinated dibenzo-p-dioxins can be formedduringthemanufacturingprocess of the chlorophenols. The amount formed depends on temperature and pressure process variability during production. The more notable toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), is formed during the production of 2,4,5- TCP. Laboratory reference standards of 2,3,7,8-TCDD are prepared by heating 2,4,5-TCP under alkaline conditions. All technical and formulated products containing 2,4,5-TCP are expected to be contaminated to varying degrees by this 2,3,7,8-TCDD by-product of the manufacturing process.
General Description
Leaflets (from ligroin) or light beige powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2,3,5,6-TETRACHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. .
Hazard
Toxic by ingestion and inhalation, strong irritant.
Fire Hazard
Flash point data for 2,3,5,6-TETRACHLOROPHENOL are not available. 2,3,5,6-TETRACHLOROPHENOL is probably combustible.
Carcinogenicity
There was no evidence of carcinogenic activity of 2,4-dichlorophenol in F344/N rats or B6C3F1 mice from the NTP bioassay program, but 2,4,6-trichlorophenol was reported to be carcinogenic in both species.
Purification Methods
Crystallise the phenol from pet ethers. The benzoate has m 136o (from EtOH). [Beilstein 6 II 182, 6 III 730, 6 IV 1025.]
Properties of 2,3,5,6-TETRACHLOROPHENOL
Melting point: | 115-116℃ (isooctane ) |
Boiling point: | 331.59°C (rough estimate) |
Density | 1.6 g/cm3 (60℃) |
refractive index | 1.5133 (estimate) |
Flash point: | 11 °C |
storage temp. | APPROX 4°C
|
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | 5.09±0.20(Predicted) |
form | neat |
Water Solubility | 0.1g/L(25 ºC) |
BRN | 2049586 |
CAS DataBase Reference | 935-95-5(CAS DataBase Reference) |
EPA Substance Registry System | 2,3,5,6-Tetrachlorophenol (935-95-5) |
Safety information for 2,3,5,6-TETRACHLOROPHENOL
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Environment GHS09 |
GHS Hazard Statements |
H301:Acute toxicity,oral H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for 2,3,5,6-TETRACHLOROPHENOL
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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